Summary | |
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Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus, trans-Golgi network Secreted, extracellular space, extracellular matrix Note=Co-localizes with POSTN in the Golgi. |
Domain |
PF01400 Astacin (Peptidase family M12A) PF00431 CUB domain PF07645 Calcium-binding EGF domain |
Function |
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX. |
Biological Process |
GO:0001501 skeletal system development GO:0001502 cartilage condensation GO:0001503 ossification GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0030509 BMP signaling pathway GO:0042157 lipoprotein metabolic process GO:0043062 extracellular structure organization GO:0048705 skeletal system morphogenesis GO:0051216 cartilage development GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO:0060395 SMAD protein signal transduction GO:0061035 regulation of cartilage development GO:0061036 positive regulation of cartilage development GO:0061448 connective tissue development GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0098743 cell aggregation |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005160 transforming growth factor beta receptor binding GO:0008083 growth factor activity GO:0008236 serine-type peptidase activity GO:0008237 metallopeptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome |
R-HSA-2214320: Anchoring fibril formation R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-1474290: Collagen formation R-HSA-2243919: Crosslinking of collagen fibrils R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1474244: Extracellular matrix organization R-HSA-194223: HDL-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BMP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BMP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BMP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BMP1 in various data sets.
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Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BMP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BMP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BMP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BMP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BMP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BMP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BMP1 |
Name | bone morphogenetic protein 1 |
Aliases | procollagen C-endopeptidase; PCOLC; OI13; TLD; mammalian tolloid protein; procollagen C-proteinase 3; Procol ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BMP1 collected from DrugBank database. |
There is no record. |