Browse BMP8A

Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF00019 Transforming growth factor beta like domain
PF00688 TGF-beta propeptide
Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0002021 response to dietary excess
GO:0002024 diet induced thermogenesis
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009306 protein secretion
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010817 regulation of hormone levels
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015833 peptide transport
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030509 BMP signaling pathway
GO:0031667 response to nutrient levels
GO:0032844 regulation of homeostatic process
GO:0042886 amide transport
GO:0044236 multicellular organism metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048871 multicellular organismal homeostasis
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051216 cartilage development
GO:0051224 negative regulation of protein transport
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0061448 connective tissue development
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0090087 regulation of peptide transport
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0097009 energy homeostasis
GO:1903531 negative regulation of secretion by cell
GO:1904950 negative regulation of establishment of protein localization
GO:1990845 adaptive thermogenesis
GO:2000505 regulation of energy homeostasis
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0008083 growth factor activity
GO:0033612 receptor serine/threonine kinase binding
GO:0070696 transmembrane receptor protein serine/threonine kinase binding
GO:0070700 BMP receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04350 TGF-beta signaling pathway
hsa04390 Hippo signaling pathway
Reactome -
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BMP8A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BMP8A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.57 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BMP8A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6890.15
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3370.725
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.9380.187
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4850.522
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0990.952
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.2320.582
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4320.269
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4750.574
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5060.535
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3920.438
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3920.59
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4830.00672
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BMP8A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BMP8A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BMP8A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BMP8A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BMP8A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BMP8A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BMP8A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBMP8A
Namebone morphogenetic protein 8a
Aliases BMP-8A
Chromosomal Location1p35-p32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BMP8A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.