Summary | |
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Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. |
Domain |
PF03908 Sec20 |
Function |
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy. |
Biological Process |
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006914 autophagy GO:0007029 endoplasmic reticulum organization GO:0016320 endoplasmic reticulum membrane fusion GO:0044801 single-organism membrane fusion GO:0048193 Golgi vesicle transport GO:0048284 organelle fusion GO:0061025 membrane fusion GO:0090174 organelle membrane fusion GO:0097194 execution phase of apoptosis |
Molecular Function |
GO:0005484 SNAP receptor activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0030176 integral component of endoplasmic reticulum membrane GO:0031201 SNARE complex GO:0031227 intrinsic component of endoplasmic reticulum membrane |
KEGG |
hsa04130 SNARE interactions in vesicular transport |
Reactome |
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BNIP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BNIP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BNIP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BNIP1 in various data sets.
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Summary | |
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Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BNIP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BNIP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BNIP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BNIP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BNIP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BNIP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BNIP1 |
Name | BCL2/adenovirus E1B 19kDa interacting protein 1 |
Aliases | SEC20; BCL2/adenovirus E1B 19kD-interacting protein 1; TRG-8; BCL2/adenovirus E1B 19 kDa protein-interacting ...... |
Chromosomal Location | 5q33-q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BNIP1 collected from DrugBank database. |
There is no record. |