Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Chromosome Note=Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. |
Domain | - |
Function |
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705). |
Biological Process |
GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0031297 replication fork processing GO:0045005 DNA-dependent DNA replication maintenance of fidelity |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BOD1L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BOD1L1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BOD1L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BOD1L1 in various data sets.
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Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BOD1L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BOD1L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BOD1L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BOD1L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BOD1L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BOD1L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | BOD1L1 |
Name | biorientation of chromosomes in cell division 1-like 1 |
Aliases | FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ...... |
Chromosomal Location | 4p16.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BOD1L1 collected from DrugBank database. |
There is no record. |