Browse BOD1L1

Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Chromosome Note=Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection.
Domain -
Function

Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).

> Gene Ontology
 
Biological Process GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0031297 replication fork processing
GO:0045005 DNA-dependent DNA replication maintenance of fidelity
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BOD1L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BOD1L1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BOD1L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0070.982
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4720.705
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3650.733
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0880.76
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.190.943
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0420.99
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2130.568
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.220.9
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2410.899
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0790.325
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.720.284
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0430.442
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BOD1L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.54.114.40.0315
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.55.113.40.102
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.3033.30.0365
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.67.75.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BOD1L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BOD1L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BOD1L1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BOD1L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BOD1L1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BOD1L1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBOD1L1
Namebiorientation of chromosomes in cell division 1-like 1
Aliases FLJ33215; KIAA1327; FAM44A; BOD1L; family with sequence similarity 44, member A; biorientation of chromosome ......
Chromosomal Location4p16.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BOD1L1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.