Summary | |
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Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM |
Function |
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). |
Biological Process |
GO:0006413 translational initiation GO:0006417 regulation of translation GO:0006446 regulation of translational initiation GO:0007126 meiotic nuclear division GO:0007283 spermatogenesis GO:0010608 posttranscriptional regulation of gene expression GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0043489 RNA stabilization GO:0045727 positive regulation of translation GO:0045948 positive regulation of translational initiation GO:0048232 male gamete generation GO:0048255 mRNA stabilization GO:0051321 meiotic cell cycle GO:0070935 3'-UTR-mediated mRNA stabilization GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0003729 mRNA binding GO:0003730 mRNA 3'-UTR binding GO:0008494 translation activator activity GO:0045182 translation regulator activity GO:0090079 translation regulator activity, nucleic acid binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BOLL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BOLL in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BOLL in various data sets.
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Points in the above scatter plot represent the mutation difference of BOLL in various data sets.
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Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BOLL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BOLL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BOLL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BOLL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BOLL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BOLL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BOLL |
Name | boule-like RNA-binding protein |
Aliases | BOULE; bol (Drosophila boule homolog)-like; bol, boule-like (Drosophila); bol, boule-like; Protein boule-lik ...... |
Chromosomal Location | 2q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BOLL collected from DrugBank database. |
There is no record. |