Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm. Cell membrane Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. |
Domain |
PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) PF07714 Protein tyrosine kinase PF02196 Raf-like Ras-binding domain |
Function |
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. |
Biological Process |
GO:0000186 activation of MAPKK activity GO:0001505 regulation of neurotransmitter levels GO:0001667 ameboidal-type cell migration GO:0002244 hematopoietic progenitor cell differentiation GO:0002318 myeloid progenitor cell differentiation GO:0002521 leukocyte differentiation GO:0006836 neurotransmitter transport GO:0006887 exocytosis GO:0007015 actin filament organization GO:0007159 leukocyte cell-cell adhesion GO:0007269 neurotransmitter secretion GO:0007409 axonogenesis GO:0007611 learning or memory GO:0007612 learning GO:0007632 visual behavior GO:0008306 associative learning GO:0008542 visual learning GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010171 body morphogenesis GO:0010720 positive regulation of cell development GO:0010761 fibroblast migration GO:0010762 regulation of fibroblast migration GO:0010764 negative regulation of fibroblast migration GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014074 response to purine-containing compound GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0016079 synaptic vesicle exocytosis GO:0017156 calcium ion regulated exocytosis GO:0017157 regulation of exocytosis GO:0017158 regulation of calcium ion-dependent exocytosis GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0019827 stem cell population maintenance GO:0022604 regulation of cell morphogenesis GO:0023061 signal release GO:0030038 contractile actin filament bundle assembly GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030336 negative regulation of cell migration GO:0030878 thyroid gland development GO:0031032 actomyosin structure organization GO:0031099 regeneration GO:0031102 neuron projection regeneration GO:0031103 axon regeneration GO:0031346 positive regulation of cell projection organization GO:0031589 cell-substrate adhesion GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033674 positive regulation of kinase activity GO:0034446 substrate adhesion-dependent cell spreading GO:0035019 somatic stem cell population maintenance GO:0035270 endocrine system development GO:0035690 cellular response to drug GO:0035710 CD4-positive, alpha-beta T cell activation GO:0040013 negative regulation of locomotion GO:0042110 T cell activation GO:0042493 response to drug GO:0043149 stress fiber assembly GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043368 positive T cell selection GO:0043405 regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0045055 regulated exocytosis GO:0045058 T cell selection GO:0045666 positive regulation of neuron differentiation GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0045920 negative regulation of exocytosis GO:0045955 negative regulation of calcium ion-dependent exocytosis GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046683 response to organophosphorus GO:0046928 regulation of neurotransmitter secretion GO:0046929 negative regulation of neurotransmitter secretion GO:0048167 regulation of synaptic plasticity GO:0048489 synaptic vesicle transport GO:0048538 thymus development GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048678 response to axon injury GO:0048679 regulation of axon regeneration GO:0048680 positive regulation of axon regeneration GO:0048732 gland development GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0050890 cognition GO:0051017 actin filament bundle assembly GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051259 protein oligomerization GO:0051271 negative regulation of cellular component movement GO:0051291 protein heterooligomerization GO:0051402 neuron apoptotic process GO:0051492 regulation of stress fiber assembly GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051496 positive regulation of stress fiber assembly GO:0051588 regulation of neurotransmitter transport GO:0051589 negative regulation of neurotransmitter transport GO:0051591 response to cAMP GO:0051592 response to calcium ion GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051962 positive regulation of nervous system development GO:0060291 long-term synaptic potentiation GO:0060323 head morphogenesis GO:0060324 face development GO:0060627 regulation of vesicle-mediated transport GO:0061564 axon development GO:0061572 actin filament bundle organization GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070570 regulation of neuron projection regeneration GO:0070572 positive regulation of neuron projection regeneration GO:0070997 neuron death GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071277 cellular response to calcium ion GO:0071593 lymphocyte aggregation GO:0071900 regulation of protein serine/threonine kinase activity GO:0072577 endothelial cell apoptotic process GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0098727 maintenance of cell number GO:0099003 vesicle-mediated transport in synapse GO:0099504 synaptic vesicle cycle GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse GO:1900024 regulation of substrate adhesion-dependent cell spreading GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901652 response to peptide GO:1902803 regulation of synaptic vesicle transport GO:1902804 negative regulation of synaptic vesicle transport GO:1903034 regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903305 regulation of regulated secretory pathway GO:1903306 negative regulation of regulated secretory pathway GO:1903531 negative regulation of secretion by cell GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:2000146 negative regulation of cell motility GO:2000300 regulation of synaptic vesicle exocytosis GO:2000301 negative regulation of synaptic vesicle exocytosis GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004709 MAP kinase kinase kinase activity GO:0005057 receptor signaling protein activity GO:0031434 mitogen-activated protein kinase kinase binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0044297 cell body |
KEGG |
hsa04010 MAPK signaling pathway hsa04012 ErbB signaling pathway hsa04015 Rap1 signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04068 FoxO signaling pathway hsa04150 mTOR signaling pathway hsa04270 Vascular smooth muscle contraction hsa04320 Dorso-ventral axis formation hsa04510 Focal adhesion hsa04650 Natural killer cell mediated cytotoxicity hsa04720 Long-term potentiation hsa04722 Neurotrophin signaling pathway hsa04726 Serotonergic synapse hsa04730 Long-term depression hsa04810 Regulation of actin cytoskeleton hsa04910 Insulin signaling pathway hsa04914 Progesterone-mediated oocyte maturation |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-422475: Axon guidance R-HSA-442742: CREB phosphorylation through the activation of Ras R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5674135: MAP2K and MAPK activation R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5674499: Negative feedback regulation of MAPK pathway R-HSA-5654726: Negative regulation of FGFR1 signaling R-HSA-5654727: Negative regulation of FGFR2 signaling R-HSA-5654732: Negative regulation of FGFR3 signaling R-HSA-5654733: Negative regulation of FGFR4 signaling R-HSA-5675221: Negative regulation of MAPK pathway R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802955: Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-438064: Post NMDA receptor activation events R-HSA-169893: Prolonged ERK activation events R-HSA-5673000: RAF activation R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-6802952: Signaling by BRAF and RAF fusions R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-5654736: Signaling by FGFR1 R-HSA-5654738: Signaling by FGFR2 R-HSA-5654741: Signaling by FGFR3 R-HSA-5654743: Signaling by FGFR4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-6802949: Signaling by RAS mutants R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-6802948: Signaling by high-kinase activity BRAF mutants R-HSA-6802946: Signaling by moderate kinase activity BRAF mutants R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-1295596: Spry regulation of FGF signaling R-HSA-112315: Transmission across Chemical Synapses R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BRAF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between BRAF and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BRAF in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BRAF in various data sets.
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Points in the above scatter plot represent the mutation difference of BRAF in various data sets.
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Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BRAF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BRAF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BRAF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BRAF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BRAF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BRAF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | BRAF |
Name | B-Raf proto-oncogene, serine/threonine kinase |
Aliases | BRAF1; v-raf murine sarcoma viral oncogene homolog B; B-RAF11; NS7; RAFB1; 94 kDa B-raf protein; B-Raf proto ...... |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BRAF collected from DrugBank database. |
Details on drugs targeting BRAF.
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