Browse BRIP1

Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF06733 DEAD_2
PF13307 Helicase C-terminal domain
Function

DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000731 DNA synthesis involved in DNA repair
GO:0000732 strand displacement
GO:0006260 DNA replication
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007584 response to nutrient
GO:0009991 response to extracellular stimulus
GO:0031570 DNA integrity checkpoint
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031670 cellular response to nutrient
GO:0032392 DNA geometric change
GO:0032508 DNA duplex unwinding
GO:0033273 response to vitamin
GO:0071103 DNA conformation change
GO:0071295 cellular response to vitamin
GO:0071496 cellular response to external stimulus
GO:0071897 DNA biosynthetic process
GO:0072331 signal transduction by p53 class mediator
GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function GO:0003678 DNA helicase activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0051540 metal cluster binding
GO:0070035 purine NTP-dependent helicase activity
Cellular Component GO:0005635 nuclear envelope
GO:0031965 nuclear membrane
> KEGG and Reactome Pathway
 
KEGG hsa03440 Homologous recombination
hsa03460 Fanconi anemia pathway
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-2564830: Cytosolic iron-sulfur cluster assembly
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-69481: G2/M Checkpoints
R-HSA-69473: G2/M DNA damage checkpoint
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5685942: HDR through Homologous Recombination (HRR)
R-HSA-5685938: HDR through Single Strand Annealing (SSA)
R-HSA-5693579: Homologous DNA Pairing and Strand Exchange
R-HSA-5693538: Homology Directed Repair
R-HSA-1430728: Metabolism
R-HSA-5693616: Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5693607: Processing of DNA double-strand break ends
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-5693537: Resolution of D-Loop Structures
R-HSA-5693568: Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693554: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BRIP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BRIP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BRIP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1860.324
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3890.451
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0420.927
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0590.907
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1830.898
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0930.961
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0310.938
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4020.748
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4910.695
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3530.429
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.10.865
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4220.000312
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BRIP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.52.715.80.0147
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.53.415.10.0291
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BRIP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BRIP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BRIP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BRIP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BRIP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BRIP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBRIP1
NameBRCA1 interacting protein C-terminal helicase 1
Aliases FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ......
Chromosomal Location17q23.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BRIP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.