Summary | |
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Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF06733 DEAD_2 PF13307 Helicase C-terminal domain |
Function |
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000731 DNA synthesis involved in DNA repair GO:0000732 strand displacement GO:0006260 DNA replication GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0031570 DNA integrity checkpoint GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0033273 response to vitamin GO:0071103 DNA conformation change GO:0071295 cellular response to vitamin GO:0071496 cellular response to external stimulus GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator |
Molecular Function |
GO:0003678 DNA helicase activity GO:0004003 ATP-dependent DNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0051536 iron-sulfur cluster binding GO:0051539 4 iron, 4 sulfur cluster binding GO:0051540 metal cluster binding GO:0070035 purine NTP-dependent helicase activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0031965 nuclear membrane |
KEGG |
hsa03440 Homologous recombination hsa03460 Fanconi anemia pathway |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-2564830: Cytosolic iron-sulfur cluster assembly R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5685942: HDR through Homologous Recombination (HRR) R-HSA-5685938: HDR through Single Strand Annealing (SSA) R-HSA-5693579: Homologous DNA Pairing and Strand Exchange R-HSA-5693538: Homology Directed Repair R-HSA-1430728: Metabolism R-HSA-5693616: Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693607: Processing of DNA double-strand break ends R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-5693537: Resolution of D-Loop Structures R-HSA-5693568: Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693554: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BRIP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BRIP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BRIP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BRIP1 in various data sets.
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Summary | |
---|---|
Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BRIP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BRIP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BRIP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BRIP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BRIP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BRIP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BRIP1 |
Name | BRCA1 interacting protein C-terminal helicase 1 |
Aliases | FANCJ; BRCA1/BRCA2-associated helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal heli ...... |
Chromosomal Location | 17q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BRIP1 collected from DrugBank database. |
There is no record. |