Summary | |
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Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass membrane protein |
Domain |
PF00023 Ankyrin repeat PF12796 Ankyrin repeats (3 copies) PF00651 BTB/POZ domain |
Function |
- |
Biological Process |
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0010498 proteasomal protein catabolic process GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0060395 SMAD protein signal transduction |
Molecular Function |
GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0019005 SCF ubiquitin ligase complex GO:0031461 cullin-RING ubiquitin ligase complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BTBD11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BTBD11 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BTBD11 in various data sets.
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Points in the above scatter plot represent the mutation difference of BTBD11 in various data sets.
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Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BTBD11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BTBD11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BTBD11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BTBD11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BTBD11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BTBD11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | BTBD11 |
Name | BTB (POZ) domain containing 11 |
Aliases | FLJ33957; ABTB2B; ANK-repeat BTB domain containing protein; BTB/POZ domain-containing protein 11; Ankyrin re ...... |
Chromosomal Location | 12q24.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BTBD11 collected from DrugBank database. |
There is no record. |