Browse BVES

Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Lateral cell membrane Cell junction, tight junction Membrane Multi-pass membrane protein Cell membrane, sarcolemma Membrane, caveola Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells.
Domain PF04831 Popeye protein conserved region
Function

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

> Gene Ontology
 
Biological Process GO:0001881 receptor recycling
GO:0001919 regulation of receptor recycling
GO:0001921 positive regulation of receptor recycling
GO:0002027 regulation of heart rate
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002931 response to ischemia
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003161 cardiac conduction system development
GO:0003163 sinoatrial node development
GO:0007034 vacuolar transport
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008360 regulation of cell shape
GO:0014706 striated muscle tissue development
GO:0016197 endosomal transport
GO:0022406 membrane docking
GO:0022604 regulation of cell morphogenesis
GO:0031589 cell-substrate adhesion
GO:0032456 endocytic recycling
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035051 cardiocyte differentiation
GO:0040017 positive regulation of locomotion
GO:0042391 regulation of membrane potential
GO:0042692 muscle cell differentiation
GO:0043112 receptor metabolic process
GO:0044057 regulation of system process
GO:0048278 vesicle docking
GO:0048738 cardiac muscle tissue development
GO:0051146 striated muscle cell differentiation
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055006 cardiac cell development
GO:0055007 cardiac muscle cell differentiation
GO:0055013 cardiac muscle cell development
GO:0060047 heart contraction
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060627 regulation of vesicle-mediated transport
GO:0060920 cardiac pacemaker cell differentiation
GO:0060921 sinoatrial node cell differentiation
GO:0060926 cardiac pacemaker cell development
GO:0060931 sinoatrial node cell development
GO:0060973 cell migration involved in heart development
GO:0090136 epithelial cell-cell adhesion
GO:1903335 regulation of vacuolar transport
GO:1903522 regulation of blood circulation
GO:2001135 regulation of endocytic recycling
Molecular Function GO:0030551 cyclic nucleotide binding
GO:0030552 cAMP binding
Cellular Component GO:0005901 caveola
GO:0005923 bicellular tight junction
GO:0016328 lateral plasma membrane
GO:0031253 cell projection membrane
GO:0042383 sarcolemma
GO:0043296 apical junction complex
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0070160 occluding junction
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04530 Tight junction
Reactome -
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between BVES and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of BVES in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of BVES in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1280.78
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0640.943
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1690.806
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4040.212
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7530.502
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0370.978
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2820.533
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0760.943
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7890.456
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3820.479
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.220.0716
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1940.297
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of BVES in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BVES. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BVES. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BVES.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BVES. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of BVES expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between BVES and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolBVES
Nameblood vessel epicardial substance
Aliases HBVES; POPDC1; popeye domain containing 1; popeye domain-containing protein 1; popeye protein 1
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting BVES collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.