Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Mitochondrion Note=Preferentially expressed in the mitochondria in the presence of TSPO. |
Domain |
PF07653 Variant SH3 domain PF14604 Variant SH3 domain |
Function |
- |
Biological Process |
GO:0001505 regulation of neurotransmitter levels GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006836 neurotransmitter transport GO:0007269 neurotransmitter secretion GO:0014047 glutamate secretion GO:0015711 organic anion transport GO:0023061 signal release GO:0046942 carboxylic acid transport GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse |
Molecular Function |
GO:0030156 benzodiazepine receptor binding |
Cellular Component |
GO:0098793 presynapse |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between BZRAP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of BZRAP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of BZRAP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of BZRAP1 in various data sets.
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Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of BZRAP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of BZRAP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by BZRAP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of BZRAP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of BZRAP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between BZRAP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | BZRAP1 |
Name | benzodiazepine receptor (peripheral) associated protein 1 |
Aliases | PRAX-1; KIAA0612; RIM-BP1; RIMBP1; PBR-IP; PRAX1; RIMS-binding protein 1; benzodiazapine receptor (periphera ...... |
Chromosomal Location | 17q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting BZRAP1 collected from DrugBank database. |
There is no record. |