Summary | |
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Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus inner membrane Single-pass membrane protein Chromosome, telomere Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. |
Domain |
PF15077 Membrane-anchored junction protein |
Function |
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. |
Biological Process |
GO:0007059 chromosome segregation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007129 synapsis GO:0034397 telomere localization GO:0034398 telomere tethering at nuclear periphery GO:0044821 meiotic telomere tethering at nuclear periphery GO:0045132 meiotic chromosome segregation GO:0045141 meiotic telomere clustering GO:0045143 homologous chromosome segregation GO:0050000 chromosome localization GO:0051303 establishment of chromosome localization GO:0051321 meiotic cell cycle GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0070192 chromosome organization involved in meiotic cell cycle GO:0070197 meiotic attachment of telomere to nuclear envelope GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation GO:0097240 chromosome attachment to the nuclear envelope GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process |
Molecular Function | - |
Cellular Component |
GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0005635 nuclear envelope GO:0005637 nuclear inner membrane GO:0005639 integral component of nuclear inner membrane GO:0031229 intrinsic component of nuclear inner membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0031965 nuclear membrane GO:0044453 nuclear membrane part GO:0044454 nuclear chromosome part GO:0098687 chromosomal region |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between C11orf85 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of C11orf85 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of C11orf85 in various data sets.
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Points in the above scatter plot represent the mutation difference of C11orf85 in various data sets.
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Summary | |
---|---|
Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of C11orf85. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of C11orf85. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by C11orf85. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of C11orf85. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of C11orf85 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | C11orf85 |
Name | chromosome 11 open reading frame 85 |
Aliases | Uncharacterized protein C11orf85 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between C11orf85 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |