Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. |
Domain |
PF00194 Eukaryotic-type carbonic anhydrase |
Function |
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. |
Biological Process |
GO:0001655 urogenital system development GO:0001822 kidney development GO:0001894 tissue homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0006730 one-carbon metabolic process GO:0006820 anion transport GO:0006821 chloride transport GO:0006857 oligopeptide transport GO:0006885 regulation of pH GO:0007270 neuron-neuron synaptic transmission GO:0009268 response to pH GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0015669 gas transport GO:0015670 carbon dioxide transport GO:0015698 inorganic anion transport GO:0015701 bicarbonate transport GO:0015711 organic anion transport GO:0015833 peptide transport GO:0019755 one-carbon compound transport GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030099 myeloid cell differentiation GO:0030316 osteoclast differentiation GO:0030641 regulation of cellular pH GO:0032228 regulation of synaptic transmission, GABAergic GO:0032230 positive regulation of synaptic transmission, GABAergic GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032847 regulation of cellular pH reduction GO:0032849 positive regulation of cellular pH reduction GO:0034103 regulation of tissue remodeling GO:0034105 positive regulation of tissue remodeling GO:0034405 response to fluid shear stress GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0035442 dipeptide transmembrane transport GO:0035672 oligopeptide transmembrane transport GO:0038166 angiotensin-activated signaling pathway GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0042886 amide transport GO:0042938 dipeptide transport GO:0043434 response to peptide hormone GO:0043627 response to estrogen GO:0044070 regulation of anion transport GO:0045124 regulation of bone resorption GO:0045453 bone resorption GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045672 positive regulation of osteoclast differentiation GO:0045780 positive regulation of bone resorption GO:0045851 pH reduction GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0046852 positive regulation of bone remodeling GO:0048545 response to steroid hormone GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050804 modulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0051452 intracellular pH reduction GO:0051453 regulation of intracellular pH GO:0051932 synaptic transmission, GABAergic GO:0055067 monovalent inorganic cation homeostasis GO:0060249 anatomical structure homeostasis GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071498 cellular response to fluid shear stress GO:0072001 renal system development GO:0090087 regulation of peptide transport GO:0090088 regulation of oligopeptide transport GO:0090089 regulation of dipeptide transport GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904385 cellular response to angiotensin GO:1990267 response to transition metal nanoparticle GO:1990776 response to angiotensin GO:2000021 regulation of ion homeostasis GO:2000878 positive regulation of oligopeptide transport GO:2000880 positive regulation of dipeptide transport GO:2001148 regulation of dipeptide transmembrane transport GO:2001150 positive regulation of dipeptide transmembrane transport GO:2001225 regulation of chloride transport |
Molecular Function |
GO:0004064 arylesterase activity GO:0004089 carbonate dehydratase activity GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0016836 hydro-lyase activity GO:0052689 carboxylic ester hydrolase activity |
Cellular Component |
GO:0005902 microvillus GO:0016323 basolateral plasma membrane GO:0030424 axon GO:0043209 myelin sheath GO:0045177 apical part of cell GO:0098858 actin-based cell projection |
KEGG |
hsa04964 Proximal tubule bicarbonate reclamation hsa04966 Collecting duct acid secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion hsa04976 Bile secretion hsa00910 Nitrogen metabolism |
Reactome |
R-HSA-1237044: Erythrocytes take up carbon dioxide and release oxygen R-HSA-1247673: Erythrocytes take up oxygen and release carbon dioxide R-HSA-1430728: Metabolism R-HSA-1480926: O2/CO2 exchange in erythrocytes R-HSA-1475029: Reversible hydration of carbon dioxide |
Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CA2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CA2 in various data sets.
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Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CA2 |
Name | carbonic anhydrase II |
Aliases | CA-II; CAII; HEL-76; carbonate dehydratase II; carbonic anhydrase C; epididymis luminal protein 76; Carbonic ...... |
Chromosomal Location | 8q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CA2 collected from DrugBank database. |
Details on drugs targeting CA2.
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