Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Nucleus, nucleolus Cell membrane Single-pass type I membrane protein Cell projection, microvillus membrane Single-pass type I membrane protein Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. |
Domain |
PF00194 Eukaryotic-type carbonic anhydrase |
Function |
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. |
Biological Process |
GO:0001666 response to hypoxia GO:0006730 one-carbon metabolic process GO:0006820 anion transport GO:0015701 bicarbonate transport GO:0015711 organic anion transport GO:0033574 response to testosterone GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042493 response to drug GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0070482 response to oxygen levels GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:1901654 response to ketone |
Molecular Function |
GO:0004089 carbonate dehydratase activity GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0016836 hydro-lyase activity |
Cellular Component |
GO:0005902 microvillus GO:0016323 basolateral plasma membrane GO:0031253 cell projection membrane GO:0031528 microvillus membrane GO:0098858 actin-based cell projection |
KEGG |
hsa00910 Nitrogen metabolism |
Reactome |
R-HSA-2262749: Cellular response to hypoxia R-HSA-2262752: Cellular responses to stress R-HSA-1430728: Metabolism R-HSA-1234174: Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-HSA-1234158: Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1475029: Reversible hydration of carbon dioxide |
Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CA9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CA9 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CA9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CA9 in various data sets.
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Points in the above scatter plot represent the mutation difference of CA9 in various data sets.
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Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CA9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CA9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CA9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CA9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CA9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CA9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CA9 |
Name | carbonic anhydrase IX |
Aliases | CAIX; RCC-associated protein G250; CA-IX; P54/58N; RCC-associated antigen G250; carbonate dehydratase IX; me ...... |
Chromosomal Location | 9p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CA9 collected from DrugBank database. |
Details on drugs targeting CA9.
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