Browse CACNA1A

Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF08763 Voltage gated calcium channel IQ domain
PF16905 Voltage-dependent L-type calcium channel
PF00520 Ion transport protein
Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).

> Gene Ontology
 
Biological Process GO:0000096 sulfur amino acid metabolic process
GO:0001505 regulation of neurotransmitter levels
GO:0001508 action potential
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006790 sulfur compound metabolic process
GO:0006816 calcium ion transport
GO:0006820 anion transport
GO:0006836 neurotransmitter transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006887 exocytosis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007269 neurotransmitter secretion
GO:0007270 neuron-neuron synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0007274 neuromuscular synaptic transmission
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008344 adult locomotory behavior
GO:0009306 protein secretion
GO:0009914 hormone transport
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010817 regulation of hormone levels
GO:0010975 regulation of neuron projection development
GO:0014051 gamma-aminobutyric acid secretion
GO:0014055 acetylcholine secretion, neurotransmission
GO:0014056 regulation of acetylcholine secretion, neurotransmission
GO:0015696 ammonium transport
GO:0015711 organic anion transport
GO:0015812 gamma-aminobutyric acid transport
GO:0015833 peptide transport
GO:0015837 amine transport
GO:0015870 acetylcholine transport
GO:0016049 cell growth
GO:0016079 synaptic vesicle exocytosis
GO:0016358 dendrite development
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0019226 transmission of nerve impulse
GO:0019318 hexose metabolic process
GO:0021510 spinal cord development
GO:0021515 cell differentiation in spinal cord
GO:0021517 ventral spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021533 cell differentiation in hindbrain
GO:0021548 pons development
GO:0021549 cerebellum development
GO:0021550 medulla oblongata development
GO:0021575 hindbrain morphogenesis
GO:0021578 hindbrain maturation
GO:0021587 cerebellum morphogenesis
GO:0021590 cerebellum maturation
GO:0021626 central nervous system maturation
GO:0021679 cerebellar molecular layer development
GO:0021680 cerebellar Purkinje cell layer development
GO:0021692 cerebellar Purkinje cell layer morphogenesis
GO:0021694 cerebellar Purkinje cell layer formation
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021697 cerebellar cortex formation
GO:0021700 developmental maturation
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021750 vestibular nucleus development
GO:0021953 central nervous system neuron differentiation
GO:0022037 metencephalon development
GO:0022604 regulation of cell morphogenesis
GO:0023061 signal release
GO:0030002 cellular anion homeostasis
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030320 cellular monovalent inorganic anion homeostasis
GO:0030534 adult behavior
GO:0030644 cellular chloride ion homeostasis
GO:0030902 hindbrain development
GO:0032222 regulation of synaptic transmission, cholinergic
GO:0032350 regulation of hormone metabolic process
GO:0032351 negative regulation of hormone metabolic process
GO:0032353 negative regulation of hormone biosynthetic process
GO:0033555 multicellular organismal response to stress
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035249 synaptic transmission, glutamatergic
GO:0035637 multicellular organismal signaling
GO:0042133 neurotransmitter metabolic process
GO:0042391 regulation of membrane potential
GO:0042445 hormone metabolic process
GO:0042446 hormone biosynthetic process
GO:0042886 amide transport
GO:0043113 receptor clustering
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044708 single-organism behavior
GO:0044723 single-organism carbohydrate metabolic process
GO:0045055 regulated exocytosis
GO:0046717 acid secretion
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046885 regulation of hormone biosynthetic process
GO:0046928 regulation of neurotransmitter secretion
GO:0046942 carboxylic acid transport
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0048489 synaptic vesicle transport
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter
GO:0048813 dendrite morphogenesis
GO:0048857 neural nucleus development
GO:0050708 regulation of protein secretion
GO:0050770 regulation of axonogenesis
GO:0050796 regulation of insulin secretion
GO:0050804 modulation of synaptic transmission
GO:0050808 synapse organization
GO:0050879 multicellular organismal movement
GO:0050881 musculoskeletal movement
GO:0050883 musculoskeletal movement, spinal reflex action
GO:0050885 neuromuscular process controlling balance
GO:0050905 neuromuscular process
GO:0051402 neuron apoptotic process
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051588 regulation of neurotransmitter transport
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051668 localization within membrane
GO:0051899 membrane depolarization
GO:0051952 regulation of amine transport
GO:0055064 chloride ion homeostasis
GO:0055074 calcium ion homeostasis
GO:0055081 anion homeostasis
GO:0055083 monovalent inorganic anion homeostasis
GO:0060004 reflex
GO:0060024 rhythmic synaptic transmission
GO:0060627 regulation of vesicle-mediated transport
GO:0061526 acetylcholine secretion
GO:0061564 axon development
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0070997 neuron death
GO:0071695 anatomical structure maturation
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072657 protein localization to membrane
GO:0086010 membrane depolarization during action potential
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090659 walking behavior
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901374 acetate ester transport
GO:1903305 regulation of regulated secretory pathway
Molecular Function GO:0000149 SNARE binding
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0008331 high voltage-gated calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0019905 syntaxin binding
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0005891 voltage-gated calcium channel complex
GO:0030425 dendrite
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0098793 presynapse
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04020 Calcium signaling pathway
hsa04721 Synaptic vesicle cycle
hsa04723 Retrograde endocannabinoid signaling
hsa04724 Glutamatergic synapse
hsa04725 Cholinergic synapse
hsa04726 Serotonergic synapse
hsa04727 GABAergic synapse
hsa04728 Dopaminergic synapse
hsa04730 Long-term depression
hsa04742 Taste transduction
Reactome R-HSA-112308: Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
R-HSA-163685: Integration of energy metabolism
R-HSA-1430728: Metabolism
R-HSA-112316: Neuronal System
R-HSA-422356: Regulation of insulin secretion
R-HSA-112315: Transmission across Chemical Synapses
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CACNA1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CACNA1A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CACNA1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2780.29
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3610.499
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2240.575
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4910.258
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5060.78
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4760.828
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.7240.122
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6890.333
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8170.276
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0440.919
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1310.83
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2230.32
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CACNA1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141742.911.831.10.0971
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1035033.316.71
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91644.46.238.20.0403
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 477514.360.70.0879
1329033130MelanomaallAnti-PD-1 (nivolumab) 382718.47.4110.285
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.814.34.51
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CACNA1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CACNA1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CACNA1A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CACNA1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CACNA1A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CACNA1A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCACNA1A
Namecalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Aliases Cav2.1; EA2; APCA; FHM; CACNL1A4; SCA6; MHP1; MHP; BI; brain calcium channel 1; brain calcium channel I; fet ......
Chromosomal Location19p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CACNA1A collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CACNA1A.
ID Name Drug Type Targets #Targets
DB00230PregabalinSmall MoleculeCACNA1A1
DB00421SpironolactoneSmall MoleculeAR, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, ......27
DB00661VerapamilSmall MoleculeADRA1A, ADRA1B, ADRA1D, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1 ......19
DB00836LoperamideSmall MoleculeCACNA1A, NR1I3, OPRD1, OPRK1, OPRM1, POMC6
DB01244BepridilSmall MoleculeATP1A1, CACNA1A, CACNA1H, CACNA2D2, KCNH2, KCNQ1, PDE1A, PDE1B, TN ......9
DB06446DotarizineSmall MoleculeCACNA1A, HTR1A, HTR2A, HTR2C4