Browse CACNA1H

Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Note=Interaction with STAC increases expression at the cell membrane.
Domain PF00520 Ion transport protein
Function

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216).

> Gene Ontology
 
Biological Process GO:0000768 syncytium formation by plasma membrane fusion
GO:0001508 action potential
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006081 cellular aldehyde metabolic process
GO:0006694 steroid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006705 mineralocorticoid biosynthetic process
GO:0006816 calcium ion transport
GO:0006936 muscle contraction
GO:0006949 syncytium formation
GO:0007338 single fertilization
GO:0007340 acrosome reaction
GO:0007517 muscle organ development
GO:0007520 myoblast fusion
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008202 steroid metabolic process
GO:0008207 C21-steroid hormone metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0008212 mineralocorticoid metabolic process
GO:0009566 fertilization
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010817 regulation of hormone levels
GO:0014902 myotube differentiation
GO:0032341 aldosterone metabolic process
GO:0032342 aldosterone biosynthetic process
GO:0034650 cortisol metabolic process
GO:0034651 cortisol biosynthetic process
GO:0034754 cellular hormone metabolic process
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035864 response to potassium ion
GO:0035865 cellular response to potassium ion
GO:0042180 cellular ketone metabolic process
GO:0042181 ketone biosynthetic process
GO:0042391 regulation of membrane potential
GO:0042445 hormone metabolic process
GO:0042446 hormone biosynthetic process
GO:0042692 muscle cell differentiation
GO:0043900 regulation of multi-organism process
GO:0043902 positive regulation of multi-organism process
GO:0044057 regulation of system process
GO:0044283 small molecule biosynthetic process
GO:0046184 aldehyde biosynthetic process
GO:0051146 striated muscle cell differentiation
GO:0051899 membrane depolarization
GO:0060046 regulation of acrosome reaction
GO:0060047 heart contraction
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0072511 divalent inorganic cation transport
GO:0086010 membrane depolarization during action potential
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1903522 regulation of blood circulation
GO:2000241 regulation of reproductive process
GO:2000243 positive regulation of reproductive process
GO:2000344 positive regulation of acrosome reaction
Molecular Function GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0008332 low voltage-gated calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
GO:0097110 scaffold protein binding
Cellular Component GO:0005891 voltage-gated calcium channel complex
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04020 Calcium signaling pathway
hsa04713 Circadian entrainment
Reactome R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-419037: NCAM1 interactions
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CACNA1H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CACNA1H in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CACNA1H in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.810.0241
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.5210.00951
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2980.594
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2250.735
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2070.944
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2590.939
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5840.279
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.670.429
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4850.594
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1610.893
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8040.594
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3030.0755
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CACNA1H in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.123.5-16.40.344
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414028.6-28.60.524
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.517.6-8.10.64
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.67.75.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CACNA1H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CACNA1H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CACNA1H.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CACNA1H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CACNA1H expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CACNA1H and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCACNA1H
Namecalcium channel, voltage-dependent, T type, alpha 1H subunit
Aliases Cav3.2; CACNA1HB; ECA6; EIG6; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; low-voltage-act ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CACNA1H collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CACNA1H.
ID Name Drug Type Targets #Targets
DB00270IsradipineSmall MoleculeCACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNA2D2, CACNB27
DB00421SpironolactoneSmall MoleculeAR, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, ......27
DB00568CinnarizineSmall MoleculeCACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CHR ......16
DB00909ZonisamideSmall MoleculeCA1, CA10, CA11, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, ......31
DB01023FelodipineSmall MoleculeCACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNA2D2, CACNB2, NR ......12
DB01054NitrendipineSmall MoleculeCACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNA2D2, CACNB2, CA ......8
DB01115NifedipineSmall MoleculeCACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNB2, KCNA1, NR1I28
DB01118AmiodaroneSmall MoleculeADRB1, CACNA1H, CACNA2D2, KCNH2, PPARG, THRA, THRB7
DB01244BepridilSmall MoleculeATP1A1, CACNA1A, CACNA1H, CACNA2D2, KCNH2, KCNQ1, PDE1A, PDE1B, TN ......9
DB01388MibefradilSmall MoleculeCACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CAC ......11
DB04841FlunarizineSmall MoleculeCACNA1G, CACNA1H, CACNA1I, HRH14
DB09061CannabidiolSmall MoleculeCACNA1G, CACNA1H, CACNA1I, CHRNA7, CNR1, CNR2, GLRA1, GLRA1, GLRA3 ......25
DB09089TrimebutineSmall MoleculeCACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CAC ......21
DB09231BenidipineSmall MoleculeCACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CAC ......12
DB09238ManidipineSmall MoleculeCACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CAC ......11