Summary | |
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Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF08473 Neuronal voltage-dependent calcium channel alpha 2acd PF13768 von Willebrand factor type A domain PF08399 VWA N-terminal |
Function |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. |
Biological Process |
GO:0003013 circulatory system process GO:0003015 heart process GO:0006816 calcium ion transport GO:0007601 visual perception GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0010959 regulation of metal ion transport GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035637 multicellular organismal signaling GO:0044057 regulation of system process GO:0050908 detection of light stimulus involved in visual perception GO:0050953 sensory perception of light stimulus GO:0050962 detection of light stimulus involved in sensory perception GO:0051924 regulation of calcium ion transport GO:0060047 heart contraction GO:0061337 cardiac conduction GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport GO:1903522 regulation of blood circulation |
Molecular Function |
GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005245 voltage-gated calcium channel activity GO:0005246 calcium channel regulator activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0016247 channel regulator activity GO:0022803 passive transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0022843 voltage-gated cation channel activity GO:0046873 metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0005891 voltage-gated calcium channel complex GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034704 calcium channel complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04260 Cardiac muscle contraction hsa04261 Adrenergic signaling in cardiomyocytes hsa04921 Oxytocin signaling pathway |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-397014: Muscle contraction R-HSA-5576892: Phase 0 - rapid depolarisation R-HSA-5576893: Phase 2 - plateau phase |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CACNA2D4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CACNA2D4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CACNA2D4 in various data sets.
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Points in the above scatter plot represent the mutation difference of CACNA2D4 in various data sets.
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Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CACNA2D4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CACNA2D4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CACNA2D4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CACNA2D4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CACNA2D4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CACNA2D4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CACNA2D4 |
Name | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
Aliases | RCD4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/d ...... |
Chromosomal Location | 12p13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CACNA2D4 collected from DrugBank database. |
There is no record. |