Summary | |
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Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell junction, synapse Cell projection, axon Note=Found in the axoplasm of myelinated axons. |
Domain |
PF08205 CD80-like C2-set immunoglobulin domain PF07686 Immunoglobulin V-set domain |
Function |
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. |
Biological Process |
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0008037 cell recognition GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0045216 cell-cell junction organization GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules |
Molecular Function |
GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0030424 axon |
KEGG | - |
Reactome |
R-HSA-418990: Adherens junctions interactions R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization |
Summary | |
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Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CADM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CADM2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CADM2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CADM2 in various data sets.
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Summary | |
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Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CADM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CADM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CADM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CADM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CADM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CADM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CADM2 |
Name | cell adhesion molecule 2 |
Aliases | NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ...... |
Chromosomal Location | 3p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CADM2 collected from DrugBank database. |
There is no record. |