Browse CADM2

Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein Cell junction, synapse Cell projection, axon Note=Found in the axoplasm of myelinated axons.
Domain PF08205 CD80-like C2-set immunoglobulin domain
PF07686 Immunoglobulin V-set domain
Function

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

> Gene Ontology
 
Biological Process GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0008037 cell recognition
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
Molecular Function GO:0050839 cell adhesion molecule binding
Cellular Component GO:0005913 cell-cell adherens junction
GO:0030424 axon
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-418990: Adherens junctions interactions
R-HSA-446728: Cell junction organization
R-HSA-1500931: Cell-Cell communication
R-HSA-421270: Cell-cell junction organization
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CADM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CADM2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CADM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0830.667
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3030.554
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3650.367
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4050.436
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.480.67
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3130.812
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1630.83
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8210.478
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.0980.408
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0830.841
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1670.79
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.820.012
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CADM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.2013.20.0705
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CADM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CADM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CADM2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CADM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CADM2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CADM2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCADM2
Namecell adhesion molecule 2
Aliases NECL3; Necl-3; SynCAM2; nectin-like 3; IGSF4D; immunoglobulin superfamily, member 4D; SynCAM 2; immunoglobul ......
Chromosomal Location3p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CADM2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.