Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum lumen Cytoplasm, cytosol Secreted, extracellular space, extracellular matrix Cell surface Sarcoplasmic reticulum lumen Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). Associated with the lytic granules in the cytolytic T-lymphocytes. |
Domain |
PF00262 Calreticulin family |
Function |
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). |
Biological Process |
GO:0002396 MHC protein complex assembly GO:0002397 MHC class I protein complex assembly GO:0002407 dendritic cell chemotaxis GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002501 peptide antigen assembly with MHC protein complex GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006417 regulation of translation GO:0006457 protein folding GO:0006611 protein export from nucleus GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006898 receptor-mediated endocytosis GO:0006909 phagocytosis GO:0006913 nucleocytoplasmic transport GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0007050 cell cycle arrest GO:0007126 meiotic nuclear division GO:0007283 spermatogenesis GO:0007507 heart development GO:0007568 aging GO:0007569 cell aging GO:0009755 hormone-mediated signaling pathway GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010226 response to lithium ion GO:0010608 posttranscriptional regulation of gene expression GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0014706 striated muscle tissue development GO:0017148 negative regulation of translation GO:0019882 antigen processing and presentation GO:0022417 protein maturation by protein folding GO:0022604 regulation of cell morphogenesis GO:0030100 regulation of endocytosis GO:0030335 positive regulation of cell migration GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030595 leukocyte chemotaxis GO:0030865 cortical cytoskeleton organization GO:0030866 cortical actin cytoskeleton organization GO:0030968 endoplasmic reticulum unfolded protein response GO:0031589 cell-substrate adhesion GO:0031647 regulation of protein stability GO:0031958 corticosteroid receptor signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032355 response to estradiol GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033574 response to testosterone GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034446 substrate adhesion-dependent cell spreading GO:0034504 protein localization to nucleus GO:0034620 cellular response to unfolded protein GO:0034975 protein folding in endoplasmic reticulum GO:0034976 response to endoplasmic reticulum stress GO:0035051 cardiocyte differentiation GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036336 dendritic cell migration GO:0036500 ATF6-mediated unfolded protein response GO:0038061 NIK/NF-kappaB signaling GO:0040017 positive regulation of locomotion GO:0040020 regulation of meiotic nuclear division GO:0042493 response to drug GO:0042692 muscle cell differentiation GO:0042921 glucocorticoid receptor signaling pathway GO:0043401 steroid hormone mediated signaling pathway GO:0045665 negative regulation of neuron differentiation GO:0045740 positive regulation of DNA replication GO:0045785 positive regulation of cell adhesion GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045807 positive regulation of endocytosis GO:0048002 antigen processing and presentation of peptide antigen GO:0048232 male gamete generation GO:0048384 retinoic acid receptor signaling pathway GO:0048385 regulation of retinoic acid receptor signaling pathway GO:0048387 negative regulation of retinoic acid receptor signaling pathway GO:0048545 response to steroid hormone GO:0048738 cardiac muscle tissue development GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050768 negative regulation of neurogenesis GO:0050821 protein stabilization GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051146 striated muscle cell differentiation GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051208 sequestering of calcium ion GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051272 positive regulation of cellular component movement GO:0051321 meiotic cell cycle GO:0051445 regulation of meiotic cell cycle GO:0051604 protein maturation GO:0051783 regulation of nuclear division GO:0051961 negative regulation of nervous system development GO:0055007 cardiac muscle cell differentiation GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0060537 muscle tissue development GO:0060627 regulation of vesicle-mediated transport GO:0061077 chaperone-mediated protein folding GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071285 cellular response to lithium ion GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0090398 cellular senescence GO:1900024 regulation of substrate adhesion-dependent cell spreading GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1901654 response to ketone GO:1903046 meiotic cell cycle process GO:2000147 positive regulation of cell motility GO:2000241 regulation of reproductive process GO:2000508 regulation of dendritic cell chemotaxis GO:2000510 positive regulation of dendritic cell chemotaxis |
Molecular Function |
GO:0001846 opsonin binding GO:0001848 complement binding GO:0001849 complement component C1q binding GO:0001948 glycoprotein binding GO:0003729 mRNA binding GO:0005178 integrin binding GO:0005506 iron ion binding GO:0030246 carbohydrate binding GO:0031625 ubiquitin protein ligase binding GO:0033218 amide binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042277 peptide binding GO:0042562 hormone binding GO:0044183 protein binding involved in protein folding GO:0044389 ubiquitin-like protein ligase binding GO:0050681 androgen receptor binding GO:0050839 cell adhesion molecule binding GO:0051082 unfolded protein binding GO:0051087 chaperone binding GO:0051427 hormone receptor binding |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0005578 proteinaceous extracellular matrix GO:0005788 endoplasmic reticulum lumen GO:0005790 smooth endoplasmic reticulum GO:0005844 polysome GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0009897 external side of plasma membrane GO:0016528 sarcoplasm GO:0016529 sarcoplasmic reticulum GO:0030055 cell-substrate junction GO:0030139 endocytic vesicle GO:0030141 secretory granule GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0031983 vesicle lumen GO:0033018 sarcoplasmic reticulum lumen GO:0042824 MHC class I peptide loading complex GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane GO:0071682 endocytic vesicle lumen GO:0097223 sperm part GO:0098552 side of membrane GO:0098553 lumenal side of endoplasmic reticulum membrane GO:0099503 secretory vesicle |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum hsa04145 Phagosome hsa04612 Antigen processing and presentation |
Reactome |
R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones R-HSA-1280218: Adaptive Immune System R-HSA-983170: Antigen Presentation R-HSA-1236975: Antigen processing-Cross presentation R-HSA-446203: Asparagine N-linked glycosylation R-HSA-168316: Assembly of Viral Components at the Budding Site R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-901042: Calnexin/calreticulin cycle R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1643685: Disease R-HSA-1236974: ER-Phagosome pathway R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168254: Influenza Infection R-HSA-168255: Influenza Life Cycle R-HSA-392499: Metabolism of proteins R-HSA-532668: N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-597592: Post-translational protein modification R-HSA-3000480: Scavenging by Class A Receptors R-HSA-3000484: Scavenging by Class F Receptors R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-5653656: Vesicle-mediated transport R-HSA-168268: Virus Assembly and Release |
Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CALR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CALR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CALR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CALR in various data sets.
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Points in the above scatter plot represent the mutation difference of CALR in various data sets.
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Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CALR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CALR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CALR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CALR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CALR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CALR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CALR |
Name | calreticulin |
Aliases | RO; cC1qR; FLJ26680; Sicca syndrome antigen A (autoantigen Ro; calreticulin); autoantigen Ro; HEL-S-99n; CRP ...... |
Chromosomal Location | 19p13.3-p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CALR collected from DrugBank database. |
Details on drugs targeting CALR.
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