Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, spindle Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle. |
Domain |
PF00168 C2 domain PF01067 Calpain large subunit PF00648 Calpain family cysteine protease |
Function |
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0051493 regulation of cytoskeleton organization |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0008017 microtubule binding GO:0008234 cysteine-type peptidase activity GO:0015631 tubulin binding |
Cellular Component |
GO:0005819 spindle GO:0005874 microtubule GO:0005876 spindle microtubule |
KEGG | - |
Reactome |
R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1474244: Extracellular matrix organization |
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CAPN6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CAPN6 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CAPN6 in various data sets.
|
Points in the above scatter plot represent the mutation difference of CAPN6 in various data sets.
|
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CAPN6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CAPN6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CAPN6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CAPN6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CAPN6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CAPN6 |
Name | calpain 6 |
Aliases | CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6 |
Chromosomal Location | Xq23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CAPN6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |