Browse CAPN6

Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, perinuclear region Cytoplasm, cytoskeleton, spindle Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Domain PF00168 C2 domain
PF01067 Calpain large subunit
PF00648 Calpain family cysteine protease
Function

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0051493 regulation of cytoskeleton organization
Molecular Function GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0008017 microtubule binding
GO:0008234 cysteine-type peptidase activity
GO:0015631 tubulin binding
Cellular Component GO:0005819 spindle
GO:0005874 microtubule
GO:0005876 spindle microtubule
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1474244: Extracellular matrix organization
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CAPN6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CAPN6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CAPN6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3960.181
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3270.571
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4490.332
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.490.046
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5390.688
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-2.690.0815
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.810.381
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.250.346
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3920.783
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.250.82
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0750.96
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3020.41
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CAPN6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277308.2-8.20.187
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275908.5-8.50.32
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CAPN6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CAPN6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CAPN6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CAPN6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CAPN6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CAPN6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCAPN6
Namecalpain 6
Aliases CAPNX; CalpM; CANPX; DJ914P14.1; calpain-like protease X-linked; calpamodulin; Calpain-6
Chromosomal LocationXq23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CAPN6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.