Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane Note=Translocates to the plasma membrane upon calcium binding. |
Domain |
PF13833 EF-hand domain pair |
Function |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. |
Biological Process |
GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0043062 extracellular structure organization |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0008234 cysteine-type peptidase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1474228: Degradation of the extracellular matrix R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-1643685: Disease R-HSA-1474244: Extracellular matrix organization R-HSA-8863678: Neurodegenerative Diseases |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CAPNS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CAPNS2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CAPNS2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of CAPNS2 in various data sets.
|
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CAPNS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CAPNS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CAPNS2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CAPNS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CAPNS2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CAPNS2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CAPNS2 |
Name | calpain, small subunit 2 |
Aliases | MGC12536; MGC14804; calcium-dependent protease small subunit 2; Calpain small subunit 2 |
Chromosomal Location | 16q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CAPNS2 collected from DrugBank database. |
There is no record. |