Browse CAPZA3

Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF01267 F-actin capping protein alpha subunit
Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).

> Gene Ontology
 
Biological Process GO:0007015 actin filament organization
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0010639 negative regulation of organelle organization
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030041 actin filament polymerization
GO:0030042 actin filament depolymerization
GO:0030832 regulation of actin filament length
GO:0030833 regulation of actin filament polymerization
GO:0030834 regulation of actin filament depolymerization
GO:0030835 negative regulation of actin filament depolymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0031333 negative regulation of protein complex assembly
GO:0032271 regulation of protein polymerization
GO:0032272 negative regulation of protein polymerization
GO:0032535 regulation of cellular component size
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0032984 macromolecular complex disassembly
GO:0043241 protein complex disassembly
GO:0043242 negative regulation of protein complex disassembly
GO:0043244 regulation of protein complex disassembly
GO:0043254 regulation of protein complex assembly
GO:0043624 cellular protein complex disassembly
GO:0048232 male gamete generation
GO:0048515 spermatid differentiation
GO:0051016 barbed-end actin filament capping
GO:0051258 protein polymerization
GO:0051261 protein depolymerization
GO:0051493 regulation of cytoskeleton organization
GO:0051494 negative regulation of cytoskeleton organization
GO:0051693 actin filament capping
GO:0090066 regulation of anatomical structure size
GO:1901879 regulation of protein depolymerization
GO:1901880 negative regulation of protein depolymerization
Molecular Function GO:0003779 actin binding
Cellular Component GO:0001669 acrosomal vesicle
GO:0005938 cell cortex
GO:0008290 F-actin capping protein complex
GO:0015629 actin cytoskeleton
GO:0030141 secretory granule
GO:0030863 cortical cytoskeleton
GO:0044448 cell cortex part
GO:0097223 sperm part
GO:0099503 secretory vesicle
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG hsa04144 Endocytosis
Reactome -
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CAPZA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CAPZA3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CAPZA3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.1050.208
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6520.208
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4370.816
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0480.815
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CAPZA3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277306.8-6.80.32
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275908.5-8.50.32
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CAPZA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CAPZA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CAPZA3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CAPZA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CAPZA3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CAPZA3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCAPZA3
Namecapping protein (actin filament) muscle Z-line, alpha 3
Aliases Gsg3; CAPPA3; HEL-S-86; CP-alpha-3; CapZ alpha-3; F-actin capping protein alpha-3 subunit; epididymis secret ......
Chromosomal Location12p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CAPZA3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.