Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Membrane raft Note=Colocalized with DPP4 in membrane rafts. |
Domain |
PF00619 Caspase recruitment domain |
Function |
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0007159 leukocyte cell-cell adhesion GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031349 positive regulation of defense response GO:0032623 interleukin-2 production GO:0032663 regulation of interleukin-2 production GO:0032743 positive regulation of interleukin-2 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033077 T cell differentiation in thymus GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042094 interleukin-2 biosynthetic process GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042110 T cell activation GO:0042113 B cell activation GO:0042129 regulation of T cell proliferation GO:0042278 purine nucleoside metabolic process GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045058 T cell selection GO:0045061 thymic T cell selection GO:0045076 regulation of interleukin-2 biosynthetic process GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045577 regulation of B cell differentiation GO:0045580 regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0046037 GMP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046651 lymphocyte proliferation GO:0046710 GDP metabolic process GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:1901068 guanosine-containing compound metabolic process GO:1901657 glycosyl compound metabolic process GO:1902105 regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis |
Molecular Function |
GO:0004385 guanylate kinase activity GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0019201 nucleotide kinase activity GO:0019205 nucleobase-containing compound kinase activity GO:0050700 CARD domain binding |
Cellular Component |
GO:0001772 immunological synapse GO:0042101 T cell receptor complex GO:0043235 receptor complex GO:0045121 membrane raft GO:0098589 membrane region GO:0098802 plasma membrane receptor complex GO:0098857 membrane microdomain |
KEGG |
hsa04064 NF-kappa B signaling pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway |
Reactome |
R-HSA-1169091: Activation of NF-kappaB in B cells R-HSA-1280218: Adaptive Immune System R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-202424: Downstream TCR signaling R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2871837: FCERI mediated NF-kB activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-202403: TCR signaling |
Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CARD11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CARD11 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CARD11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CARD11 in various data sets.
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Points in the above scatter plot represent the mutation difference of CARD11 in various data sets.
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Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CARD11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CARD11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CARD11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CARD11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CARD11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CARD11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CARD11 |
Name | caspase recruitment domain family, member 11 |
Aliases | CARMA1; BIMP3; card-maguk protein 1; bcl10-interacting maguk protein 3; BENTA; IMD11; PPBL; CARD-containing ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CARD11 collected from DrugBank database. |
There is no record. |