Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cytoplasm ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm ; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm |
Domain |
PF00619 Caspase recruitment domain PF00625 Guanylate kinase |
Function |
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. ; FUNCTION: Isoform 3: Not able to activate the inflammatory transcription factor NF-kappa-B and may fuction as a dominant negative regulator (PubMed:21302310, PubMed:26358359). |
Biological Process |
GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0032147 activation of protein kinase activity GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033674 positive regulation of kinase activity GO:0034612 response to tumor necrosis factor GO:0038061 NIK/NF-kappaB signaling GO:0045860 positive regulation of protein kinase activity GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0071356 cellular response to tumor necrosis factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling |
Molecular Function |
GO:0050700 CARD domain binding |
Cellular Component | - |
KEGG |
hsa04064 NF-kappa B signaling pathway |
Reactome | - |
Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CARD14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CARD14 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CARD14 in various data sets.
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Points in the above scatter plot represent the mutation difference of CARD14 in various data sets.
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Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CARD14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CARD14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CARD14. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CARD14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CARD14 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CARD14 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CARD14 |
Name | caspase recruitment domain family, member 14 |
Aliases | CARMA2; BIMP2; PSORS2; psoriasis susceptibility 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CARD14 collected from DrugBank database. |
There is no record. |