Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane. |
Domain |
PF11531 Coactivator-associated arginine methyltransferase 1 N terminal |
Function |
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0001501 skeletal system development GO:0003416 endochondral bone growth GO:0003417 growth plate cartilage development GO:0003419 growth plate cartilage chondrocyte proliferation GO:0003420 regulation of growth plate cartilage chondrocyte proliferation GO:0006479 protein methylation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007568 aging GO:0008213 protein alkylation GO:0009755 hormone-mediated signaling pathway GO:0010721 negative regulation of cell development GO:0010948 negative regulation of cell cycle process GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014074 response to purine-containing compound GO:0016358 dendrite development GO:0016570 histone modification GO:0016571 histone methylation GO:0018195 peptidyl-arginine modification GO:0018216 peptidyl-arginine methylation GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031345 negative regulation of cell projection organization GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0032091 negative regulation of protein binding GO:0032259 methylation GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0034969 histone arginine methylation GO:0034970 histone H3-R2 methylation GO:0034971 histone H3-R17 methylation GO:0035246 peptidyl-arginine N-methylation GO:0035247 peptidyl-arginine omega-N-methylation GO:0035265 organ growth GO:0042770 signal transduction in response to DNA damage GO:0043393 regulation of protein binding GO:0043401 steroid hormone mediated signaling pathway GO:0043414 macromolecule methylation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046620 regulation of organ growth GO:0046683 response to organophosphorus GO:0048545 response to steroid hormone GO:0048638 regulation of developmental growth GO:0048705 skeletal system morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051216 cartilage development GO:0051591 response to cAMP GO:0051961 negative regulation of nervous system development GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0061035 regulation of cartilage development GO:0061448 connective tissue development GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0098868 bone growth GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902415 regulation of mRNA binding GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903010 regulation of bone development GO:1905214 regulation of RNA binding GO:2000027 regulation of organ morphogenesis GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000171 negative regulation of dendrite development |
Molecular Function |
GO:0003713 transcription coactivator activity GO:0008013 beta-catenin binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008469 histone-arginine N-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016273 arginine N-methyltransferase activity GO:0016274 protein-arginine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity GO:0035642 histone methyltransferase activity (H3-R17 specific) GO:0042054 histone methyltransferase activity GO:0042393 histone binding GO:0070577 lysine-acetylated histone binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG | - |
Reactome |
R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-1368108: BMAL1 R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-3214858: RMTs methylate histone arginines R-HSA-1368082: RORA activates gene expression R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression |
Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CARM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CARM1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CARM1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CARM1 in various data sets.
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Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CARM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CARM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CARM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CARM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CARM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CARM1 |
Name | coactivator-associated arginine methyltransferase 1 |
Aliases | PRMT4; Histone-arginine methyltransferase CARM1 |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CARM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |