Browse CASP1

Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF00619 Caspase recruitment domain
Function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590).

> Gene Ontology
 
Biological Process GO:0001666 response to hypoxia
GO:0001819 positive regulation of cytokine production
GO:0002237 response to molecule of bacterial origin
GO:0006914 autophagy
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0010506 regulation of autophagy
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0014074 response to purine-containing compound
GO:0016485 protein processing
GO:0032496 response to lipopolysaccharide
GO:0032610 interleukin-1 alpha production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032650 regulation of interleukin-1 alpha production
GO:0032651 regulation of interleukin-1 beta production
GO:0032652 regulation of interleukin-1 production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0033198 response to ATP
GO:0036293 response to decreased oxygen levels
GO:0042391 regulation of membrane potential
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045862 positive regulation of proteolysis
GO:0046683 response to organophosphorus
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050702 interleukin-1 beta secretion
GO:0050703 interleukin-1 alpha secretion
GO:0050704 regulation of interleukin-1 secretion
GO:0050705 regulation of interleukin-1 alpha secretion
GO:0050706 regulation of interleukin-1 beta secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050716 positive regulation of interleukin-1 secretion
GO:0050717 positive regulation of interleukin-1 alpha secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0051047 positive regulation of secretion
GO:0051222 positive regulation of protein transport
GO:0051604 protein maturation
GO:0051881 regulation of mitochondrial membrane potential
GO:0051882 mitochondrial depolarization
GO:0051899 membrane depolarization
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060081 membrane hyperpolarization
GO:0070265 necrotic cell death
GO:0070269 pyroptosis
GO:0070482 response to oxygen levels
GO:0071214 cellular response to abiotic stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071496 cellular response to external stimulus
GO:0097300 programmed necrotic cell death
GO:1901998 toxin transport
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0008047 enzyme activator activity
GO:0008234 cysteine-type peptidase activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016504 peptidase activator activity
GO:0016505 peptidase activator activity involved in apoptotic process
GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process
GO:0061134 peptidase regulator activity
Cellular Component GO:0044445 cytosolic part
GO:0061702 inflammasome complex
GO:0072557 IPAF inflammasome complex
GO:0072558 NLRP1 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097169 AIM2 inflammasome complex
> KEGG and Reactome Pathway
 
KEGG hsa04621 NOD-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-168256: Immune System
R-HSA-622312: Inflammasomes
R-HSA-168249: Innate Immune System
R-HSA-448706: Interleukin-1 processing
R-HSA-168638: NOD1/2 Signaling Pathway
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-449147: Signaling by Interleukins
R-HSA-6803207: TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes
R-HSA-844615: The AIM2 inflammasome
R-HSA-844623: The IPAF inflammasome
R-HSA-844456: The NLRP3 inflammasome
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CASP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CASP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28442553Pancreatic CarcinomaInhibit immunity (T cell function)Pharmacological inhibition or deletion of NLRP3, ASC (apoptosis-associated speck-like protein containing a CARD complex), or caspase-1 protected against PDA and was associated with immunogenic reprogramming of innate and adaptive immunity within the TME.
29653983squamous cell carcinomaInhibit immunityTaken together, our findings demonstrated that caspase-1 in MDSCs is a direct T cell-independent mediator of tumor proliferation.
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CASP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CASP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7080.179
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.1030.644
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4320.786
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1370.698
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4650.726
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2770.868
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2740.607
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0930.953
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.780.674
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9780.598
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3040.658
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.260.0621
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CASP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CASP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CASP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CASP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CASP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CASP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CASP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCASP1
Namecaspase 1, apoptosis-related cysteine peptidase
Aliases caspase-1; interleukin 1, beta, convertase; IL1BC; caspase 1, apoptosis-related cysteine protease (interleuk ......
Chromosomal Location11q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CASP1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CASP1.
ID Name Drug Type Targets #Targets
DB01017MinocyclineSmall MoleculeALOX5, CASP1, CASP3, CYCS, IL1B, MMP9, VEGFA7
DB04875PralnacasanSmall MoleculeCASP11
DB05301LAX-101Small MoleculeCASP1, PLD12
DB05408EmricasanSmall MoleculeCASP1, CASP3, CASP73
DB05507VX-765Small MoleculeCASP1, IL1B2
DB077331-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDESmall MoleculeCASP11
DB07744Z-Val-Ala-Asp fluoromethyl ketoneSmall MoleculeCASP11
DB079163-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACIDSmall MoleculeCASP11