Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain | - |
Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
Biological Process |
GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0097194 execution phase of apoptosis |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0008234 cysteine-type peptidase activity GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process |
Cellular Component | - |
KEGG |
hsa04210 Apoptosis |
Reactome |
R-HSA-109581: Apoptosis R-HSA-111465: Apoptotic cleavage of cellular proteins R-HSA-75153: Apoptotic execution phase R-HSA-352238: Breakdown of the nuclear lamina R-HSA-264870: Caspase-mediated cleavage of cytoskeletal proteins R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5357801: Programmed Cell Death R-HSA-6803207: TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CASP6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CASP6 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CASP6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CASP6 in various data sets.
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Points in the above scatter plot represent the mutation difference of CASP6 in various data sets.
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Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CASP6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CASP6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CASP6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CASP6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CASP6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CASP6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CASP6 |
Name | caspase 6, apoptosis-related cysteine peptidase |
Aliases | caspase 6, apoptosis-related cysteine protease; apoptotic protease MCH-2; CASP-6; Caspase-6 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CASP6 collected from DrugBank database. |
There is no record. |