Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain | - |
Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. |
Biological Process |
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045862 positive regulation of proteolysis GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0097194 execution phase of apoptosis GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0008234 cysteine-type peptidase activity GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Cellular Component | - |
KEGG |
hsa04210 Apoptosis hsa04668 TNF signaling pathway |
Reactome |
R-HSA-111459: Activation of caspases through apoptosome-mediated cleavage R-HSA-109581: Apoptosis R-HSA-111465: Apoptotic cleavage of cellular proteins R-HSA-75153: Apoptotic execution phase R-HSA-111471: Apoptotic factor-mediated response R-HSA-264870: Caspase-mediated cleavage of cytoskeletal proteins R-HSA-111461: Cytochrome c-mediated apoptotic response R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-5357801: Programmed Cell Death R-HSA-111463: SMAC binds to IAPs R-HSA-111469: SMAC-mediated apoptotic response R-HSA-111464: SMAC-mediated dissociation of IAP |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CASP7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CASP7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CASP7 in various data sets.
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There is no record. |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CASP7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CASP7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CASP7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CASP7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CASP7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CASP7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CASP7 |
Name | caspase 7, apoptosis-related cysteine peptidase |
Aliases | MCH3; CMH-1; ICE-LAP3; caspase 7, apoptosis-related cysteine protease; CASP-7; LICE2; ICE-like apoptotic pro ...... |
Chromosomal Location | 10q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CASP7 collected from DrugBank database. |
Details on drugs targeting CASP7.
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