Summary | |
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Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. |
Domain |
PF00520 Ion transport protein |
Function |
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. |
Biological Process |
GO:0001508 action potential GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007338 single fertilization GO:0008037 cell recognition GO:0009566 fertilization GO:0009988 cell-cell recognition GO:0015672 monovalent inorganic cation transport GO:0021700 developmental maturation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030317 flagellated sperm motility GO:0032570 response to progesterone GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035036 sperm-egg recognition GO:0042391 regulation of membrane potential GO:0048232 male gamete generation GO:0048240 sperm capacitation GO:0048469 cell maturation GO:0048515 spermatid differentiation GO:0048545 response to steroid hormone GO:0051899 membrane depolarization GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport GO:0086010 membrane depolarization during action potential GO:0097722 sperm motility GO:1901654 response to ketone |
Molecular Function |
GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005245 voltage-gated calcium channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0022843 voltage-gated cation channel activity GO:0046873 metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0005891 voltage-gated calcium channel complex GO:0005929 cilium GO:0030141 secretory granule GO:0031514 motile cilium GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034704 calcium channel complex GO:0036128 CatSper complex GO:0097223 sperm part GO:0099503 secretory vesicle GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG | - |
Reactome |
R-HSA-1187000: Fertilization R-HSA-1474165: Reproduction R-HSA-1300642: Sperm Motility And Taxes |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CATSPER3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CATSPER3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CATSPER3 in various data sets.
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Points in the above scatter plot represent the mutation difference of CATSPER3 in various data sets.
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Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CATSPER3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CATSPER3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CATSPER3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CATSPER3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CATSPER3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CATSPER3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CATSPER3 |
Name | cation channel, sperm associated 3 |
Aliases | CACRC; ca(v)-like protein; calcium channel repeat containing 1; one-repeat calcium channel-like protein; put ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CATSPER3 collected from DrugBank database. |
There is no record. |