Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Note=Upon EGF stimulation, associates with endocytic vesicles. |
Domain |
PF02262 CBL proto-oncogene N-terminal domain 1 PF02761 CBL proto-oncogene N-terminus PF02762 CBL proto-oncogene N-terminus |
Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. |
Biological Process |
GO:0000209 protein polyubiquitination GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0006606 protein import into nucleus GO:0006607 NLS-bearing protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007173 epidermal growth factor receptor signaling pathway GO:0007175 negative regulation of epidermal growth factor-activated receptor activity GO:0007176 regulation of epidermal growth factor-activated receptor activity GO:0010469 regulation of receptor activity GO:0017038 protein import GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0033673 negative regulation of kinase activity GO:0034504 protein localization to nucleus GO:0038127 ERBB signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0042326 negative regulation of phosphorylation GO:0044744 protein targeting to nucleus GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051348 negative regulation of transferase activity GO:0061097 regulation of protein tyrosine kinase activity GO:0061099 negative regulation of protein tyrosine kinase activity GO:1901184 regulation of ERBB signaling pathway GO:1901185 negative regulation of ERBB signaling pathway GO:1902593 single-organism nuclear import GO:2000272 negative regulation of receptor activity |
Molecular Function |
GO:0001784 phosphotyrosine binding GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0017124 SH3 domain binding GO:0019787 ubiquitin-like protein transferase activity GO:0030971 receptor tyrosine kinase binding GO:0045309 protein phosphorylated amino acid binding GO:0051219 phosphoprotein binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity GO:1990782 protein tyrosine kinase binding |
Cellular Component |
GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04012 ErbB signaling pathway hsa04120 Ubiquitin mediated proteolysis hsa04144 Endocytosis hsa04660 T cell receptor signaling pathway hsa04910 Insulin signaling pathway |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System R-HSA-983705: Signaling by the B Cell Receptor (BCR) |
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CBLB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CBLB and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CBLB in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CBLB in various data sets.
|
Points in the above scatter plot represent the mutation difference of CBLB in various data sets.
|
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CBLB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CBLB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CBLB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CBLB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CBLB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CBLB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CBLB |
Name | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Aliases | RNF56; Cbl-b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Cas-Br-M (murine) ecotropic ret ...... |
Chromosomal Location | 3q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CBLB collected from DrugBank database. |
There is no record. |