Summary | |
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Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Note=Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin. |
Domain |
PF17218 CBX family C-terminal motif PF00385 Chromo (CHRromatin Organisation MOdifier) domain |
Function |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). |
Biological Process |
GO:0007548 sex differentiation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0045137 development of primary sexual characteristics |
Molecular Function |
GO:0003682 chromatin binding GO:0035064 methylated histone binding GO:0042393 histone binding |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0000785 chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0031519 PcG protein complex GO:0035102 PRC1 complex |
KEGG | - |
Reactome |
R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CBX2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CBX2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CBX2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CBX2 in various data sets.
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Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CBX2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CBX2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CBX2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CBX2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CBX2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CBX2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CBX2 |
Name | chromobox homolog 2 |
Aliases | MGC10561; Pc class homolog (Drosophila); CDCA6; chromobox homolog 2 (Drosophila Pc class); cell division cyc ...... |
Chromosomal Location | 17q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CBX2 collected from DrugBank database. |
There is no record. |