TISIDB

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted
Domain	PF01391 Collagen triple helix repeat (20 copies) PF07645 Calcium-binding EGF domain
Function	Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.

> Gene Ontology [ TOP ]
Biological Process	GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001819 positive regulation of cytokine production GO:0001945 lymph vessel development GO:0001946 lymphangiogenesis GO:0002040 sprouting angiogenesis GO:0003016 respiratory system process GO:0007585 respiratory gaseous exchange GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010954 positive regulation of protein processing GO:0016485 protein processing GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0036303 lymph vessel morphogenesis GO:0038084 vascular endothelial growth factor signaling pathway GO:0040017 positive regulation of locomotion GO:0043542 endothelial cell migration GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045862 positive regulation of proteolysis GO:0048514 blood vessel morphogenesis GO:0048845 venous blood vessel morphogenesis GO:0051272 positive regulation of cellular component movement GO:0051604 protein maturation GO:0060541 respiratory system development GO:0060841 venous blood vessel development GO:0070613 regulation of protein processing GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090287 regulation of cellular response to growth factor stimulus GO:1900746 regulation of vascular endothelial growth factor signaling pathway GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway GO:1901342 regulation of vasculature development GO:1901490 regulation of lymphangiogenesis GO:1901492 positive regulation of lymphangiogenesis GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus GO:1903317 regulation of protein maturation GO:1903319 positive regulation of protein maturation GO:1904018 positive regulation of vasculature development GO:2000147 positive regulation of cell motility
Molecular Function	GO:0002020 protease binding GO:0005518 collagen binding
Cellular Component	GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between CCBE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of CCBE1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of CCBE1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.38	0.12
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.142	0.766
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.55	0.183
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.032	0.944
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.403	0.75
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.443	0.751
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.686	0.252
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.421	0.634
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-2.058	0.0221
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.75	0.356
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.821	0.44
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.897	0.00503

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of CCBE1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	6.8	-3.1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	8.5	-4.8	0.66
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	11.8	2.5	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	18.2	-2.8	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCBE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCBE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCBE1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCBE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of CCBE1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between CCBE1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	CCBE1
Name	collagen and calcium binding EGF domains 1
Aliases	FLJ30681; KIAA1983; HKLLS1; full of fluid protein homolog; Collagen and calcium-binding EGF domain-containin ......
Chromosomal Location	18q21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting CCBE1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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