Browse CCDC151

Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium axoneme
Domain -
Function

Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0003341 cilium movement
GO:0007018 microtubule-based movement
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0010927 cellular component assembly involved in morphogenesis
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0035082 axoneme assembly
GO:0036158 outer dynein arm assembly
GO:0042384 cilium assembly
GO:0044782 cilium organization
GO:0060271 cilium morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0070286 axonemal dynein complex assembly
GO:1902017 regulation of cilium assembly
GO:1902115 regulation of organelle assembly
Molecular Function -
Cellular Component GO:0005813 centrosome
GO:0005814 centriole
GO:0005929 cilium
GO:0005930 axoneme
GO:0036064 ciliary basal body
GO:0044441 ciliary part
GO:0044450 microtubule organizing center part
GO:0097014 ciliary plasm
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CCDC151 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CCDC151 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CCDC151 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2410.307
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2310.601
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2480.5
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4340.414
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7090.475
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0910.941
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.630.194
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2550.784
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.0610.291
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0310.967
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.7550.456
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0550.744
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CCDC151 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCDC151. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCDC151. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCDC151.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCDC151. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CCDC151 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CCDC151 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCCDC151
Namecoiled-coil domain containing 151
Aliases MGC20983; CILD30; Coiled-coil domain-containing protein 151
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CCDC151 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.