Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). |
Biological Process |
GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0002548 monocyte chemotaxis GO:0007015 actin filament organization GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0030041 actin filament polymerization GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030838 positive regulation of actin filament polymerization GO:0031334 positive regulation of protein complex assembly GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032271 regulation of protein polymerization GO:0032273 positive regulation of protein polymerization GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0034341 response to interferon-gamma GO:0034612 response to tumor necrosis factor GO:0040017 positive regulation of locomotion GO:0043254 regulation of protein complex assembly GO:0043410 positive regulation of MAPK cascade GO:0044089 positive regulation of cellular component biogenesis GO:0048247 lymphocyte chemotaxis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050900 leukocyte migration GO:0051258 protein polymerization GO:0051272 positive regulation of cellular component movement GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070555 response to interleukin-1 GO:0071346 cellular response to interferon-gamma GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071621 granulocyte chemotaxis GO:0071674 mononuclear cell migration GO:0072676 lymphocyte migration GO:0090066 regulation of anatomical structure size GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1990266 neutrophil migration GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0008009 chemokine activity GO:0042379 chemokine receptor binding GO:0048020 CCR chemokine receptor binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome | - |
Summary | |
---|---|
Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCL26 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCL26 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCL26 in various data sets.
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There is no record. |
Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCL26. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCL26. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCL26. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCL26. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCL26 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCL26 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CCL26 |
Name | chemokine (C-C motif) ligand 26 |
Aliases | MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1; macrophage inflammatory protein 4-alpha; small inducible cytokin ...... |
Chromosomal Location | 7q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCL26 collected from DrugBank database. |
There is no record. |