Browse CCL28

Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00048 Small cytokines (intecrine/chemokine)
Function

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

> Gene Ontology
 
Biological Process GO:0001952 regulation of cell-matrix adhesion
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002683 negative regulation of immune system process
GO:0002685 regulation of leukocyte migration
GO:0002686 negative regulation of leukocyte migration
GO:0002691 regulation of cellular extravasation
GO:0002692 negative regulation of cellular extravasation
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0009991 response to extracellular stimulus
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030336 negative regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0031667 response to nutrient levels
GO:0040013 negative regulation of locomotion
GO:0045123 cellular extravasation
GO:0045785 positive regulation of cell adhesion
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051271 negative regulation of cellular component movement
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055074 calcium ion homeostasis
GO:0060326 cell chemotaxis
GO:0061756 leukocyte adhesion to vascular endothelial cell
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903236 regulation of leukocyte tethering or rolling
GO:1903237 negative regulation of leukocyte tethering or rolling
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell
GO:2000146 negative regulation of cell motility
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0008009 chemokine activity
GO:0042379 chemokine receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
hsa04062 Chemokine signaling pathway
hsa04672 Intestinal immune network for IgA production
Reactome R-HSA-380108: Chemokine receptors bind chemokines
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418594: G alpha (i) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CCL28 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CCL28 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CCL28 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1670.589
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0750.955
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3480.703
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5650.202
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8260.363
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2410.831
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.5460.129
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0110.992
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.1280.326
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4230.762
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5160.781
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0160.94
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CCL28 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCL28. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCL28. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCL28.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCL28. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CCL28 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CCL28 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCCL28
Namechemokine (C-C motif) ligand 28
Aliases SCYA28; MEC; CCK1; CC chemokine CCL28; mucosae-associated epithelial chemokine; small inducible cytokine sub ......
Chromosomal Location5p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CCL28 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.