Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). |
Biological Process |
GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002274 myeloid leukocyte activation GO:0002407 dendritic cell chemotaxis GO:0002544 chronic inflammatory response GO:0002548 monocyte chemotaxis GO:0002676 regulation of chronic inflammatory response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0006413 translational initiation GO:0006417 regulation of translation GO:0006446 regulation of translational initiation GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006887 exocytosis GO:0006925 inflammatory cell apoptotic process GO:0007159 leukocyte cell-cell adhesion GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009306 protein secretion GO:0009615 response to virus GO:0009636 response to toxic substance GO:0009914 hormone transport GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010533 regulation of activation of Janus kinase activity GO:0010534 regulation of activation of JAK2 kinase activity GO:0010535 positive regulation of activation of JAK2 kinase activity GO:0010536 positive regulation of activation of Janus kinase activity GO:0010608 posttranscriptional regulation of gene expression GO:0010758 regulation of macrophage chemotaxis GO:0010759 positive regulation of macrophage chemotaxis GO:0010817 regulation of hormone levels GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010820 positive regulation of T cell chemotaxis GO:0010959 regulation of metal ion transport GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014812 muscle cell migration GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014911 positive regulation of smooth muscle cell migration GO:0015833 peptide transport GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0019080 viral gene expression GO:0019083 viral transcription GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0031349 positive regulation of defense response GO:0031584 activation of phospholipase D activity GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032496 response to lipopolysaccharide GO:0032897 negative regulation of viral transcription GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033002 muscle cell proliferation GO:0033028 myeloid cell apoptotic process GO:0033032 regulation of myeloid cell apoptotic process GO:0033033 negative regulation of myeloid cell apoptotic process GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033630 positive regulation of cell adhesion mediated by integrin GO:0033631 cell-cell adhesion mediated by integrin GO:0033632 regulation of cell-cell adhesion mediated by integrin GO:0033634 positive regulation of cell-cell adhesion mediated by integrin GO:0033674 positive regulation of kinase activity GO:0034109 homotypic cell-cell adhesion GO:0034110 regulation of homotypic cell-cell adhesion GO:0034112 positive regulation of homotypic cell-cell adhesion GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034341 response to interferon-gamma GO:0034612 response to tumor necrosis factor GO:0035747 natural killer cell chemotaxis GO:0035821 modification of morphology or physiology of other organism GO:0036230 granulocyte activation GO:0036336 dendritic cell migration GO:0040017 positive regulation of locomotion GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042119 neutrophil activation GO:0042129 regulation of T cell proliferation GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042886 amide transport GO:0042976 activation of Janus kinase activity GO:0042977 activation of JAK2 kinase activity GO:0043270 positive regulation of ion transport GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0043921 modulation by host of viral transcription GO:0043922 negative regulation by host of viral transcription GO:0044033 multi-organism metabolic process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045069 regulation of viral genome replication GO:0045070 positive regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045727 positive regulation of translation GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0045948 positive regulation of translational initiation GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046651 lymphocyte proliferation GO:0046782 regulation of viral transcription GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048245 eosinophil chemotaxis GO:0048246 macrophage chemotaxis GO:0048247 lymphocyte chemotaxis GO:0048524 positive regulation of viral process GO:0048525 negative regulation of viral process GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050708 regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050792 regulation of viral process GO:0050796 regulation of insulin secretion GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051259 protein oligomerization GO:0051262 protein tetramerization GO:0051272 positive regulation of cellular component movement GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0052312 modulation of transcription in other organism involved in symbiotic interaction GO:0052472 modulation by host of symbiont transcription GO:0055074 calcium ion homeostasis GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060326 cell chemotaxis GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0061097 regulation of protein tyrosine kinase activity GO:0061098 positive regulation of protein tyrosine kinase activity GO:0070098 chemokine-mediated signaling pathway GO:0070099 regulation of chemokine-mediated signaling pathway GO:0070100 negative regulation of chemokine-mediated signaling pathway GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070229 negative regulation of lymphocyte apoptotic process GO:0070230 positive regulation of lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070232 regulation of T cell apoptotic process GO:0070233 negative regulation of T cell apoptotic process GO:0070234 positive regulation of T cell apoptotic process GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070555 response to interleukin-1 GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0070838 divalent metal ion transport GO:0070997 neuron death GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071346 cellular response to interferon-gamma GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071593 lymphocyte aggregation GO:0071621 granulocyte chemotaxis GO:0071622 regulation of granulocyte chemotaxis GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0071774 response to fibroblast growth factor GO:0071887 leukocyte apoptotic process GO:0071888 macrophage apoptotic process GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072676 lymphocyte migration GO:0072677 eosinophil migration GO:0072678 T cell migration GO:0090025 regulation of monocyte chemotaxis GO:0090026 positive regulation of monocyte chemotaxis GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:0097696 STAT cascade GO:1901214 regulation of neuron death GO:1901623 regulation of lymphocyte chemotaxis GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1903902 positive regulation of viral life cycle GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1990266 neutrophil migration GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000108 positive regulation of leukocyte apoptotic process GO:2000109 regulation of macrophage apoptotic process GO:2000110 negative regulation of macrophage apoptotic process GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration GO:2000501 regulation of natural killer cell chemotaxis GO:2000503 positive regulation of natural killer cell chemotaxis |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0004435 phosphatidylinositol phospholipase C activity GO:0004620 phospholipase activity GO:0004629 phospholipase C activity GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0008009 chemokine activity GO:0008047 enzyme activator activity GO:0008081 phosphoric diester hydrolase activity GO:0016004 phospholipase activator activity GO:0016298 lipase activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0030296 protein tyrosine kinase activator activity GO:0030298 receptor signaling protein tyrosine kinase activator activity GO:0030545 receptor regulator activity GO:0030547 receptor inhibitor activity GO:0031726 CCR1 chemokine receptor binding GO:0031729 CCR4 chemokine receptor binding GO:0031730 CCR5 chemokine receptor binding GO:0042056 chemoattractant activity GO:0042379 chemokine receptor binding GO:0042578 phosphoric ester hydrolase activity GO:0043621 protein self-association GO:0046817 chemokine receptor antagonist activity GO:0048019 receptor antagonist activity GO:0048020 CCR chemokine receptor binding GO:0060229 lipase activator activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04668 TNF signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCL5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CCL5 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCL5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCL5 in various data sets.
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There is no record. |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCL5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCL5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCL5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCL5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCL5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCL5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CCL5 |
Name | chemokine (C-C motif) ligand 5 |
Aliases | RANTES; SISd; TCP228; MGC17164; T-cell specific protein p288; T-cell specific RANTES protein; SIS-delta; reg ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCL5 collected from DrugBank database. |
Details on drugs targeting CCL5.
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