Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. |
Biological Process |
GO:0002548 monocyte chemotaxis GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0008360 regulation of cell shape GO:0009314 response to radiation GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0022604 regulation of cell morphogenesis GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0034341 response to interferon-gamma GO:0034612 response to tumor necrosis factor GO:0035747 natural killer cell chemotaxis GO:0040017 positive regulation of locomotion GO:0043410 positive regulation of MAPK cascade GO:0045471 response to ethanol GO:0048245 eosinophil chemotaxis GO:0048247 lymphocyte chemotaxis GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070555 response to interleukin-1 GO:0071346 cellular response to interferon-gamma GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071361 cellular response to ethanol GO:0071621 granulocyte chemotaxis GO:0071674 mononuclear cell migration GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072676 lymphocyte migration GO:0072677 eosinophil migration GO:0097305 response to alcohol GO:0097306 cellular response to alcohol GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1901623 regulation of lymphocyte chemotaxis GO:1990266 neutrophil migration GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000501 regulation of natural killer cell chemotaxis GO:2000503 positive regulation of natural killer cell chemotaxis |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005539 glycosaminoglycan binding GO:0008009 chemokine activity GO:0008201 heparin binding GO:0031726 CCR1 chemokine receptor binding GO:0031727 CCR2 chemokine receptor binding GO:0042379 chemokine receptor binding GO:0048020 CCR chemokine receptor binding GO:1901681 sulfur compound binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome | - |
Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCL7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CCL7 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCL7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCL7 in various data sets.
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Points in the above scatter plot represent the mutation difference of CCL7 in various data sets.
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Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCL7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCL7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCL7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCL7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCL7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCL7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CCL7 |
Name | chemokine (C-C motif) ligand 7 |
Aliases | MCP-3; NC28; FIC; MARC; MCP3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; SCYA6; SCY ...... |
Chromosomal Location | 17q11.2-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCL7 collected from DrugBank database. |
There is no record. |