Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
Domain |
PF02984 Cyclin PF00134 Cyclin |
Function |
Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000086 G2/M transition of mitotic cell cycle GO:0000819 sister chromatid segregation GO:0001101 response to acid chemical GO:0001556 oocyte maturation GO:0001666 response to hypoxia GO:0001701 in utero embryonic development GO:0001933 negative regulation of protein phosphorylation GO:0006323 DNA packaging GO:0006397 mRNA processing GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006997 nucleus organization GO:0006998 nuclear envelope organization GO:0007050 cell cycle arrest GO:0007052 mitotic spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007077 mitotic nuclear envelope disassembly GO:0007080 mitotic metaphase plate congression GO:0007088 regulation of mitotic nuclear division GO:0007091 metaphase/anaphase transition of mitotic cell cycle GO:0007093 mitotic cell cycle checkpoint GO:0007094 mitotic spindle assembly checkpoint GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007292 female gamete generation GO:0007346 regulation of mitotic cell cycle GO:0007507 heart development GO:0007517 muscle organ development GO:0008608 attachment of spindle microtubules to kinetochore GO:0009612 response to mechanical stimulus GO:0009636 response to toxic substance GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009994 oocyte differentiation GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010039 response to iron ion GO:0010041 response to iron(III) ion GO:0010498 proteasomal protein catabolic process GO:0010639 negative regulation of organelle organization GO:0010948 negative regulation of cell cycle process GO:0010965 regulation of mitotic sister chromatid separation GO:0014706 striated muscle tissue development GO:0014855 striated muscle cell proliferation GO:0016202 regulation of striated muscle tissue development GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0017085 response to insecticide GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0021700 developmental maturation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030071 regulation of mitotic metaphase/anaphase transition GO:0030261 chromosome condensation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030397 membrane disassembly GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031099 regeneration GO:0031123 RNA 3'-end processing GO:0031124 mRNA 3'-end processing GO:0031145 anaphase-promoting complex-dependent catabolic process GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0031440 regulation of mRNA 3'-end processing GO:0031442 positive regulation of mRNA 3'-end processing GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031577 spindle checkpoint GO:0033002 muscle cell proliferation GO:0033044 regulation of chromosome organization GO:0033045 regulation of sister chromatid segregation GO:0033046 negative regulation of sister chromatid segregation GO:0033047 regulation of mitotic sister chromatid segregation GO:0033048 negative regulation of mitotic sister chromatid segregation GO:0033127 regulation of histone phosphorylation GO:0033129 positive regulation of histone phosphorylation GO:0035051 cardiocyte differentiation GO:0035265 organ growth GO:0035404 histone-serine phosphorylation GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042176 regulation of protein catabolic process GO:0042246 tissue regeneration GO:0042326 negative regulation of phosphorylation GO:0042493 response to drug GO:0042692 muscle cell differentiation GO:0042770 signal transduction in response to DNA damage GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043987 histone H3-S10 phosphorylation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044784 metaphase/anaphase transition of cell cycle GO:0044819 mitotic G1/S transition checkpoint GO:0044839 cell cycle G2/M phase transition GO:0044843 cell cycle G1/S phase transition GO:0045732 positive regulation of protein catabolic process GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045839 negative regulation of mitotic nuclear division GO:0045841 negative regulation of mitotic metaphase/anaphase transition GO:0045844 positive regulation of striated muscle tissue development GO:0045862 positive regulation of proteolysis GO:0045927 positive regulation of growth GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0046680 response to DDT GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048232 male gamete generation GO:0048469 cell maturation GO:0048477 oogenesis GO:0048565 digestive tract development GO:0048599 oocyte development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048738 cardiac muscle tissue development GO:0050000 chromosome localization GO:0050684 regulation of mRNA processing GO:0050685 positive regulation of mRNA processing GO:0051081 nuclear envelope disassembly GO:0051146 striated muscle cell differentiation GO:0051303 establishment of chromosome localization GO:0051304 chromosome separation GO:0051306 mitotic sister chromatid separation GO:0051310 metaphase plate congression GO:0051348 negative regulation of transferase activity GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051443 positive regulation of ubiquitin-protein transferase activity GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0051783 regulation of nuclear division GO:0051784 negative regulation of nuclear division GO:0051983 regulation of chromosome segregation GO:0051984 positive regulation of chromosome segregation GO:0051985 negative regulation of chromosome segregation GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore GO:0051988 regulation of attachment of spindle microtubules to kinetochore GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055012 ventricular cardiac muscle cell differentiation GO:0055013 cardiac muscle cell development GO:0055015 ventricular cardiac muscle cell development GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0055123 digestive system development GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060537 muscle tissue development GO:0060623 regulation of chromosome condensation GO:0070482 response to oxygen levels GO:0070542 response to fatty acid GO:0071103 DNA conformation change GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071173 spindle assembly checkpoint GO:0071174 mitotic spindle checkpoint GO:0071229 cellular response to acid chemical GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071281 cellular response to iron ion GO:0071283 cellular response to iron(III) ion GO:0071396 cellular response to lipid GO:0071398 cellular response to fatty acid GO:0071407 cellular response to organic cyclic compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0090231 regulation of spindle checkpoint GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint GO:0098813 nuclear chromosome segregation GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1901976 regulation of cell cycle checkpoint GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902099 regulation of metaphase/anaphase transition of cell cycle GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle GO:1902275 regulation of chromatin organization GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903311 regulation of mRNA metabolic process GO:1903313 positive regulation of mRNA metabolic process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903504 regulation of mitotic spindle checkpoint GO:1904666 regulation of ubiquitin protein ligase activity GO:1904667 negative regulation of ubiquitin protein ligase activity GO:1904668 positive regulation of ubiquitin protein ligase activity GO:1905269 positive regulation of chromatin organization GO:1990267 response to transition metal nanoparticle GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000775 histone H3-S10 phosphorylation involved in chromosome condensation GO:2000816 negative regulation of mitotic sister chromatid separation GO:2001251 negative regulation of chromosome organization |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0005113 patched binding GO:0035173 histone kinase activity GO:0097472 cyclin-dependent protein kinase activity |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000778 condensed nuclear chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000780 condensed nuclear chromosome, centromeric region GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000922 spindle pole GO:0000940 condensed chromosome outer kinetochore GO:0000942 condensed nuclear chromosome outer kinetochore GO:0005813 centrosome GO:0005819 spindle GO:0044454 nuclear chromosome part GO:0098687 chromosomal region |
KEGG |
hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04114 Oocyte meiosis hsa04115 p53 signaling pathway hsa04914 Progesterone-mediated oocyte maturation |
Reactome |
R-HSA-174143: APC/C-mediated degradation of cell cycle proteins R-HSA-174048: APC/C R-HSA-176409: APC/C R-HSA-176814: Activation of APC/C and APC/C R-HSA-2980767: Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-380287: Centrosome maturation R-HSA-75035: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B R-HSA-2514853: Condensation of Prometaphase Chromosomes R-HSA-2299718: Condensation of Prophase Chromosomes R-HSA-69273: Cyclin A/B1 associated events during G2/M transition R-HSA-4419969: Depolymerisation of the Nuclear Lamina R-HSA-113510: E2F mediated regulation of DNA replication R-HSA-113507: E2F-enabled inhibition of pre-replication complex formation R-HSA-69206: G1/S Transition R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-69478: G2/M DNA replication checkpoint R-HSA-69275: G2/M Transition R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162658: Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-68886: M Phase R-HSA-2465910: MASTL Facilitates Mitotic Progression R-HSA-453279: Mitotic G1-G1/S phases R-HSA-453274: Mitotic G2-G2/M phases R-HSA-68877: Mitotic Prometaphase R-HSA-68875: Mitotic Prophase R-HSA-2980766: Nuclear Envelope Breakdown R-HSA-3301854: Nuclear Pore Complex (NPC) Disassembly R-HSA-176417: Phosphorylation of Emi1 R-HSA-176412: Phosphorylation of the APC/C R-HSA-156711: Polo-like kinase mediated events R-HSA-380320: Recruitment of NuMA to mitotic centrosomes R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes R-HSA-176408: Regulation of APC/C activators between G1/S and early anaphase R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-453276: Regulation of mitotic cell cycle R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCNB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CCNB1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCNB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCNB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CCNB1 in various data sets.
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Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCNB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCNB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCNB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCNB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCNB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CCNB1 |
Name | cyclin B1 |
Aliases | G2/mitotic-specific cyclin B1; CCNB; G2/mitotic-specific cyclin-B1 |
Chromosomal Location | 5q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCNB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |