Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). ; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. |
Biological Process |
GO:0001525 angiogenesis GO:0001819 positive regulation of cytokine production GO:0001974 blood vessel remodeling GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002278 eosinophil activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002407 dendritic cell chemotaxis GO:0002434 immune complex clearance GO:0002436 immune complex clearance by monocytes and macrophages GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002447 eosinophil mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002548 monocyte chemotaxis GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002691 regulation of cellular extravasation GO:0002693 positive regulation of cellular extravasation GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002825 regulation of T-helper 1 type immune response GO:0002827 positive regulation of T-helper 1 type immune response GO:0002828 regulation of type 2 immune response GO:0002829 negative regulation of type 2 immune response GO:0002886 regulation of myeloid leukocyte mediated immunity GO:0002887 negative regulation of myeloid leukocyte mediated immunity GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006887 exocytosis GO:0006968 cellular defense response GO:0007159 leukocyte cell-cell adhesion GO:0007194 negative regulation of adenylate cyclase activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007259 JAK-STAT cascade GO:0008347 glial cell migration GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010720 positive regulation of cell development GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010820 positive regulation of T cell chemotaxis GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0016525 negative regulation of angiogenesis GO:0017157 regulation of exocytosis GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030800 negative regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030803 negative regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030809 negative regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030815 negative regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030818 negative regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031280 negative regulation of cyclase activity GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032609 interferon-gamma production GO:0032623 interleukin-2 production GO:0032640 tumor necrosis factor production GO:0032649 regulation of interferon-gamma production GO:0032663 regulation of interleukin-2 production GO:0032680 regulation of tumor necrosis factor production GO:0032729 positive regulation of interferon-gamma production GO:0032743 positive regulation of interleukin-2 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0035696 monocyte extravasation GO:0035697 CD8-positive, alpha-beta T cell extravasation GO:0035700 astrocyte chemotaxis GO:0035701 hematopoietic stem cell migration GO:0035704 helper T cell chemotaxis GO:0035705 T-helper 17 cell chemotaxis GO:0036230 granulocyte activation GO:0036336 dendritic cell migration GO:0040017 positive regulation of locomotion GO:0042035 regulation of cytokine biosynthetic process GO:0042063 gliogenesis GO:0042088 T-helper 1 type immune response GO:0042089 cytokine biosynthetic process GO:0042092 type 2 immune response GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042533 tumor necrosis factor biosynthetic process GO:0042534 regulation of tumor necrosis factor biosynthetic process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process GO:0043299 leukocyte degranulation GO:0043300 regulation of leukocyte degranulation GO:0043301 negative regulation of leukocyte degranulation GO:0043307 eosinophil activation GO:0043308 eosinophil degranulation GO:0043309 regulation of eosinophil degranulation GO:0043310 negative regulation of eosinophil degranulation GO:0043615 astrocyte cell migration GO:0045055 regulated exocytosis GO:0045123 cellular extravasation GO:0045761 regulation of adenylate cyclase activity GO:0045765 regulation of angiogenesis GO:0045785 positive regulation of cell adhesion GO:0045920 negative regulation of exocytosis GO:0045980 negative regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046631 alpha-beta T cell activation GO:0046633 alpha-beta T cell proliferation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046640 regulation of alpha-beta T cell proliferation GO:0046641 positive regulation of alpha-beta T cell proliferation GO:0046651 lymphocyte proliferation GO:0048247 lymphocyte chemotaxis GO:0048514 blood vessel morphogenesis GO:0048771 tissue remodeling GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050769 positive regulation of neurogenesis GO:0050777 negative regulation of immune response GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0051339 regulation of lyase activity GO:0051350 negative regulation of lyase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0051962 positive regulation of nervous system development GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0060627 regulation of vesicle-mediated transport GO:0070098 chemokine-mediated signaling pathway GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0071706 tumor necrosis factor superfamily cytokine production GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072522 purine-containing compound biosynthetic process GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0072683 T cell extravasation GO:0090025 regulation of monocyte chemotaxis GO:0090026 positive regulation of monocyte chemotaxis GO:0090264 regulation of immune complex clearance by monocytes and macrophages GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages GO:0097529 myeloid leukocyte migration GO:0097696 STAT cascade GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900372 negative regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901623 regulation of lymphocyte chemotaxis GO:1902566 regulation of eosinophil activation GO:1902567 negative regulation of eosinophil activation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903305 regulation of regulated secretory pathway GO:1903306 negative regulation of regulated secretory pathway GO:1903531 negative regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903975 regulation of glial cell migration GO:1903977 positive regulation of glial cell migration GO:2000147 positive regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration GO:2000407 regulation of T cell extravasation GO:2000409 positive regulation of T cell extravasation GO:2000437 regulation of monocyte extravasation GO:2000439 positive regulation of monocyte extravasation GO:2000449 regulation of CD8-positive, alpha-beta T cell extravasation GO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation GO:2000458 regulation of astrocyte chemotaxis GO:2000464 positive regulation of astrocyte chemotaxis GO:2000471 regulation of hematopoietic stem cell migration GO:2000473 positive regulation of hematopoietic stem cell migration |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0001664 G-protein coupled receptor binding GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0005126 cytokine receptor binding GO:0008528 G-protein coupled peptide receptor activity GO:0016493 C-C chemokine receptor activity GO:0031727 CCR2 chemokine receptor binding GO:0042379 chemokine receptor binding GO:0048020 CCR chemokine receptor binding |
Cellular Component |
GO:0030425 dendrite GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0044297 cell body |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-6803157: Antimicrobial peptides R-HSA-1461957: Beta defensins R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1461973: Defensins R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CCR2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CCR2 in various data sets.
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Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CCR2 |
Name | chemokine (C-C motif) receptor 2 |
Aliases | CC-CKR-2; CKR2; MCP-1-R; CD192; FLJ78302; CMKBR2; CCR-2A; CCR2B; CKR2A; CKR2B; MCP-1 receptor; monocyte chem ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCR2 collected from DrugBank database. |
Details on drugs targeting CCR2.
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