Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. |
Biological Process |
GO:0001525 angiogenesis GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006968 cellular defense response GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0070098 chemokine-mediated signaling pathway GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:1901342 regulation of vasculature development GO:1904018 positive regulation of vasculature development |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016493 C-C chemokine receptor activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CCR3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCR3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of CCR3 in various data sets.
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Summary | |
---|---|
Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CCR3 |
Name | chemokine (C-C motif) receptor 3 |
Aliases | CC-CKR-3; CKR3; CD193; CMKBR3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil C ...... |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCR3 collected from DrugBank database. |
There is no record. |