Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
Biological Process |
GO:0001764 neuron migration GO:0002507 tolerance induction GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0009314 response to radiation GO:0032103 positive regulation of response to external stimulus GO:0040017 positive regulation of locomotion GO:0046677 response to antibiotic GO:0048872 homeostasis of number of cells GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050927 positive regulation of positive chemotaxis GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0070098 chemokine-mediated signaling pathway GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016493 C-C chemokine receptor activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCR4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CCR4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCR4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCR4 in various data sets.
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Points in the above scatter plot represent the mutation difference of CCR4 in various data sets.
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Summary | |
---|---|
Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCR4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCR4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCR4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCR4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCR4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCR4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CCR4 |
Name | chemokine (C-C motif) receptor 4 |
Aliases | CC-CKR-4; CMKBR4; CKR4; k5-5; CD194; HGCN:14099; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; CD antigen CD ...... |
Chromosomal Location | 3p24-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCR4 collected from DrugBank database. |
There is no record. |