Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00403 Heavy-metal-associated domain PF00080 Copper/zinc superoxide dismutase (SODC) |
Function |
Delivers copper to copper zinc superoxide dismutase (SOD1). |
Biological Process |
GO:0000041 transition metal ion transport GO:0000302 response to reactive oxygen species GO:0000303 response to superoxide GO:0000305 response to oxygen radical GO:0006801 superoxide metabolic process GO:0006825 copper ion transport GO:0006979 response to oxidative stress GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0015680 intracellular copper ion transport GO:0019430 removal of superoxide radicals GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0051341 regulation of oxidoreductase activity GO:0051353 positive regulation of oxidoreductase activity GO:0071450 cellular response to oxygen radical GO:0071451 cellular response to superoxide GO:0072593 reactive oxygen species metabolic process GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification |
Molecular Function |
GO:0004784 superoxide dismutase activity GO:0005507 copper ion binding GO:0008047 enzyme activator activity GO:0015035 protein disulfide oxidoreductase activity GO:0015036 disulfide oxidoreductase activity GO:0016209 antioxidant activity GO:0016530 metallochaperone activity GO:0016531 copper chaperone activity GO:0016532 superoxide dismutase copper chaperone activity GO:0016667 oxidoreductase activity, acting on a sulfur group of donors GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction |
KEGG | - |
Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-3299685: Detoxification of Reactive Oxygen Species |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CCS in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCS in various data sets.
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Points in the above scatter plot represent the mutation difference of CCS in various data sets.
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Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCS. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCS expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCS and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CCS |
Name | copper chaperone for superoxide dismutase |
Aliases | superoxide dismutase copper chaperone |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCS collected from DrugBank database. |
Details on drugs targeting CCS.
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