Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body |
Domain |
PF00118 TCP-1/cpn60 chaperonin family |
Function |
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. |
Biological Process |
GO:0000723 telomere maintenance GO:0006278 RNA-dependent DNA biosynthetic process GO:0006403 RNA localization GO:0006457 protein folding GO:0007004 telomere maintenance via telomerase GO:0007338 single fertilization GO:0007339 binding of sperm to zona pellucida GO:0008037 cell recognition GO:0009566 fertilization GO:0009988 cell-cell recognition GO:0010833 telomere maintenance via telomere lengthening GO:0031647 regulation of protein stability GO:0032200 telomere organization GO:0032204 regulation of telomere maintenance GO:0032206 positive regulation of telomere maintenance GO:0032210 regulation of telomere maintenance via telomerase GO:0032212 positive regulation of telomere maintenance via telomerase GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033044 regulation of chromosome organization GO:0034502 protein localization to chromosome GO:0034504 protein localization to nucleus GO:0035036 sperm-egg recognition GO:0046931 pore complex assembly GO:0050821 protein stabilization GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0060249 anatomical structure homeostasis GO:0070198 protein localization to chromosome, telomeric region GO:0070199 establishment of protein localization to chromosome GO:0070200 establishment of protein localization to telomere GO:0070202 regulation of establishment of protein localization to chromosome GO:0070203 regulation of establishment of protein localization to telomere GO:0071897 DNA biosynthetic process GO:0090670 RNA localization to Cajal body GO:0090671 telomerase RNA localization to Cajal body GO:0090672 telomerase RNA localization GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901998 toxin transport GO:1903405 protein localization to nuclear body GO:1903829 positive regulation of cellular protein localization GO:1904356 regulation of telomere maintenance via telomere lengthening GO:1904358 positive regulation of telomere maintenance via telomere lengthening GO:1904814 regulation of protein localization to chromosome, telomeric region GO:1904816 positive regulation of protein localization to chromosome, telomeric region GO:1904851 positive regulation of establishment of protein localization to telomere GO:1904867 protein localization to Cajal body GO:1904869 regulation of protein localization to Cajal body GO:1904871 positive regulation of protein localization to Cajal body GO:1904872 regulation of telomerase RNA localization to Cajal body GO:1904874 positive regulation of telomerase RNA localization to Cajal body GO:1904951 positive regulation of establishment of protein localization GO:1990173 protein localization to nucleoplasm GO:2000278 regulation of DNA biosynthetic process GO:2000573 positive regulation of DNA biosynthetic process GO:2001252 positive regulation of chromosome organization |
Molecular Function |
GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0051082 unfolded protein binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0002199 zona pellucida receptor complex GO:0005813 centrosome GO:0005832 chaperonin-containing T-complex GO:0005874 microtubule GO:0005913 cell-cell adherens junction GO:0005929 cilium GO:0044297 cell body GO:0044445 cytosolic part GO:0045111 intermediate filament cytoskeleton |
KEGG | - |
Reactome |
R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis R-HSA-5620922: BBSome-mediated cargo-targeting to cilium R-HSA-5620920: Cargo trafficking to the periciliary membrane R-HSA-390466: Chaperonin-mediated protein folding R-HSA-5617833: Cilium Assembly R-HSA-6814122: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-389958: Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390450: Folding of actin by CCT/TriC R-HSA-389960: Formation of tubulin folding intermediates by CCT/TriC R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-6798695: Neutrophil degranulation R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-391251: Protein folding |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CCT8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CCT8 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CCT8 in various data sets.
|
Points in the above scatter plot represent the mutation difference of CCT8 in various data sets.
|
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCT8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCT8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCT8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCT8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CCT8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CCT8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CCT8 |
Name | chaperonin containing TCP1, subunit 8 (theta) |
Aliases | Cctq; PRED71; C21orf112; chromosome 21 open reading frame 112; D21S246; CCT-theta; TCP-1-theta; renal carcin ...... |
Chromosomal Location | 21q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CCT8 collected from DrugBank database. |
There is no record. |