Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Soluble CD163: Secreted ; SUBCELLULAR LOCATION: Cell membrane Single-pass type I membrane protein Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. |
Domain |
PF00530 Scavenger receptor cysteine-rich domain |
Function |
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. |
Biological Process |
GO:0002526 acute inflammatory response GO:0006898 receptor-mediated endocytosis GO:0006953 acute-phase response |
Molecular Function |
GO:0005044 scavenger receptor activity GO:0038024 cargo receptor activity |
Cellular Component |
GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane |
KEGG | - |
Reactome |
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2168880: Scavenging of heme from plasma R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD163 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD163 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD163 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD163 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD163 in various data sets.
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Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD163. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD163. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD163. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD163. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD163 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD163 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD163 |
Name | CD163 molecule |
Aliases | MM130; CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; CD antigen CD163; Scaven ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD163 collected from DrugBank database. |
Details on drugs targeting CD163.
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