Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Membrane raft Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). |
Domain |
PF07654 Immunoglobulin C1-set domain PF16497 MHC-I family domain |
Function |
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. |
Biological Process |
GO:0002250 adaptive immune response GO:0002475 antigen processing and presentation via MHC class Ib GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib |
Molecular Function |
GO:0003823 antigen binding GO:0030881 beta-2-microglobulin binding GO:0030882 lipid antigen binding GO:0030883 endogenous lipid antigen binding GO:0030884 exogenous lipid antigen binding GO:0033218 amide binding GO:0042277 peptide binding GO:0071723 lipopeptide binding |
Cellular Component |
GO:0010008 endosome membrane GO:0044440 endosomal part GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04530 Tight junction hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD1A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD1A in various data sets.
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Points in the above scatter plot represent the mutation difference of CD1A in various data sets.
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Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD1A |
Name | CD1a molecule |
Aliases | CD1A antigen, a polypeptide; CD1a antigen; FCB6; HTA1; R4; T-cell surface antigen T6/Leu-6; cluster of diffe ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD1A collected from DrugBank database. |
Details on drugs targeting CD1A.
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