Summary | |
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Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; SUBCELLULAR LOCATION: T-cell surface glycoprotein CD1e, soluble: Lysosome lumen. |
Domain |
PF07654 Immunoglobulin C1-set domain PF16497 MHC-I family domain |
Function |
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. |
Biological Process |
GO:0002250 adaptive immune response GO:0002475 antigen processing and presentation via MHC class Ib GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib |
Molecular Function |
GO:0003823 antigen binding GO:0030881 beta-2-microglobulin binding GO:0030882 lipid antigen binding GO:0030883 endogenous lipid antigen binding GO:0030884 exogenous lipid antigen binding GO:0033218 amide binding GO:0042277 peptide binding GO:0071723 lipopeptide binding |
Cellular Component |
GO:0005769 early endosome GO:0005770 late endosome GO:0005775 vacuolar lumen GO:0043202 lysosomal lumen |
KEGG |
hsa04530 Tight junction hsa04640 Hematopoietic cell lineage |
Reactome | - |
Summary | |
---|---|
Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD1E and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD1E in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD1E in various data sets.
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Points in the above scatter plot represent the mutation difference of CD1E in various data sets.
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Summary | |
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Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD1E. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD1E. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD1E. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD1E. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD1E expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD1E and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CD1E |
Name | CD1e molecule |
Aliases | CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD1E collected from DrugBank database. |
There is no record. |