Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF05790 Immunoglobulin C2-set domain PF07686 Immunoglobulin V-set domain |
Function |
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. |
Biological Process |
GO:0001766 membrane raft polarization GO:0001773 myeloid dendritic cell activation GO:0001819 positive regulation of cytokine production GO:0002274 myeloid leukocyte activation GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0007159 leukocyte cell-cell adhesion GO:0009306 protein secretion GO:0022407 regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030101 natural killer cell activation GO:0030217 T cell differentiation GO:0030885 regulation of myeloid dendritic cell activation GO:0030887 positive regulation of myeloid dendritic cell activation GO:0031579 membrane raft organization GO:0031580 membrane raft distribution GO:0032609 interferon-gamma production GO:0032637 interleukin-8 production GO:0032640 tumor necrosis factor production GO:0032649 regulation of interferon-gamma production GO:0032677 regulation of interleukin-8 production GO:0032680 regulation of tumor necrosis factor production GO:0032729 positive regulation of interferon-gamma production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0034113 heterotypic cell-cell adhesion GO:0042110 T cell activation GO:0045580 regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050900 leukocyte migration GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051665 membrane raft localization GO:0051668 localization within membrane GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0071706 tumor necrosis factor superfamily cytokine production GO:0072606 interleukin-8 secretion GO:0072643 interferon-gamma secretion GO:1902105 regulation of leukocyte differentiation GO:1902713 regulation of interferon-gamma secretion GO:1902715 positive regulation of interferon-gamma secretion GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903532 positive regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903706 regulation of hemopoiesis GO:1904951 positive regulation of establishment of protein localization GO:2000482 regulation of interleukin-8 secretion GO:2000484 positive regulation of interleukin-8 secretion |
Molecular Function | - |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0009898 cytoplasmic side of plasma membrane GO:0031225 anchored component of membrane GO:0046658 anchored component of plasma membrane GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis |
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD2 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CD2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of CD2 in various data sets.
|
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CD2 |
Name | CD2 molecule |
Aliases | CD2 antigen (p50), sheep red blood cell receptor; LFA-2; T11; LFA-3 receptor; T-cell surface antigen T11/Leu ...... |
Chromosomal Location | 1p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD2 collected from DrugBank database. |
Details on drugs targeting CD2.
|