Summary | |
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Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type II membrane protein Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes. |
Domain |
PF00059 Lectin C-type domain |
Function |
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
Biological Process |
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0006898 receptor-mediated endocytosis GO:0009615 response to virus GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0048002 antigen processing and presentation of peptide antigen GO:0051607 defense response to virus GO:0098542 defense response to other organism |
Molecular Function |
GO:0005537 mannose binding GO:0030246 carbohydrate binding GO:0048029 monosaccharide binding |
Cellular Component |
GO:0005769 early endosome GO:0010008 endosome membrane GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0031901 early endosome membrane GO:0044440 endosomal part GO:0045334 clathrin-coated endocytic vesicle |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1236978: Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-168256: Immune System |
Summary | |
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Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD207 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD207 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD207 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD207 in various data sets.
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Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD207. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD207. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD207. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD207. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD207 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD207 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CD207 |
Name | CD207 molecule, langerin |
Aliases | Langerin; CLEC4K; CD207 antigen, langerin; C-type lectin domain family 4, member K; Langerhans cell specific ...... |
Chromosomal Location | 2p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD207 collected from DrugBank database. |
There is no record. |