Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein Cell membrane Note=Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs. |
Domain |
PF13895 Immunoglobulin domain PF11465 Natural killer cell receptor 2B4 |
Function |
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). |
Biological Process |
GO:0001773 myeloid dendritic cell activation GO:0001787 natural killer cell proliferation GO:0001819 positive regulation of cytokine production GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002285 lymphocyte activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0006066 alcohol metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0007159 leukocyte cell-cell adhesion GO:0009306 protein secretion GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010919 regulation of inositol phosphate biosynthetic process GO:0016051 carbohydrate biosynthetic process GO:0019751 polyol metabolic process GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030101 natural killer cell activation GO:0032609 interferon-gamma production GO:0032637 interleukin-8 production GO:0032649 regulation of interferon-gamma production GO:0032677 regulation of interleukin-8 production GO:0032729 positive regulation of interferon-gamma production GO:0032757 positive regulation of interleukin-8 production GO:0032814 regulation of natural killer cell activation GO:0032816 positive regulation of natural killer cell activation GO:0032817 regulation of natural killer cell proliferation GO:0032819 positive regulation of natural killer cell proliferation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0032958 inositol phosphate biosynthetic process GO:0035740 CD8-positive, alpha-beta T cell proliferation GO:0036037 CD8-positive, alpha-beta T cell activation GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0043255 regulation of carbohydrate biosynthetic process GO:0043647 inositol phosphate metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0045785 positive regulation of cell adhesion GO:0045913 positive regulation of carbohydrate metabolic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:0046631 alpha-beta T cell activation GO:0046633 alpha-beta T cell proliferation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046640 regulation of alpha-beta T cell proliferation GO:0046641 positive regulation of alpha-beta T cell proliferation GO:0046651 lymphocyte proliferation GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0071613 granzyme B production GO:0071661 regulation of granzyme B production GO:0071663 positive regulation of granzyme B production GO:0072606 interleukin-8 secretion GO:0072643 interferon-gamma secretion GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902713 regulation of interferon-gamma secretion GO:1902715 positive regulation of interferon-gamma secretion GO:1902930 regulation of alcohol biosynthetic process GO:1902932 positive regulation of alcohol biosynthetic process GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization GO:2000482 regulation of interleukin-8 secretion GO:2000484 positive regulation of interleukin-8 secretion GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation GO:2001185 regulation of CD8-positive, alpha-beta T cell activation GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation |
Molecular Function |
GO:0042287 MHC protein binding GO:0042288 MHC class I protein binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis |
Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD244 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD244 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD244 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD244 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD244 in various data sets.
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Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD244. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD244. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD244. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD244. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD244 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD244 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD244 |
Name | CD244 molecule, natural killer cell receptor 2B4 |
Aliases | 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; N ...... |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD244 collected from DrugBank database. |
There is no record. |