Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF00020 TNFR/NGFR cysteine-rich region |
Function |
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007253 cytoplasmic sequestering of NF-kappaB GO:0007254 JNK cascade GO:0008588 release of cytoplasmic sequestered NF-kappaB GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016064 immunoglobulin mediated immune response GO:0017038 protein import GO:0019724 B cell mediated immunity GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0031098 stress-activated protein kinase signaling cascade GO:0031503 protein complex localization GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032496 response to lipopolysaccharide GO:0032507 maintenance of protein location in cell GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033157 regulation of intracellular protein transport GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034504 protein localization to nucleus GO:0034612 response to tumor necrosis factor GO:0042113 B cell activation GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042308 negative regulation of protein import into nucleus GO:0042345 regulation of NF-kappaB import into nucleus GO:0042346 positive regulation of NF-kappaB import into nucleus GO:0042347 negative regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042992 negative regulation of transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0042994 cytoplasmic sequestering of transcription factor GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043410 positive regulation of MAPK cascade GO:0044744 protein targeting to nucleus GO:0045185 maintenance of protein location GO:0045471 response to ethanol GO:0045577 regulation of B cell differentiation GO:0045579 positive regulation of B cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045861 negative regulation of proteolysis GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046822 regulation of nucleocytoplasmic transport GO:0046823 negative regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0051051 negative regulation of transport GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051220 cytoplasmic sequestering of protein GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051235 maintenance of location GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0051651 maintenance of location in cell GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070229 negative regulation of lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070232 regulation of T cell apoptotic process GO:0070233 negative regulation of T cell apoptotic process GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0071356 cellular response to tumor necrosis factor GO:0071887 leukocyte apoptotic process GO:0090316 positive regulation of intracellular protein transport GO:0090317 negative regulation of intracellular protein transport GO:0097191 extrinsic apoptotic signaling pathway GO:0097305 response to alcohol GO:1900180 regulation of protein localization to nucleus GO:1900181 negative regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903828 negative regulation of cellular protein localization GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904590 negative regulation of protein import GO:1904591 positive regulation of protein import GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0005031 tumor necrosis factor-activated receptor activity GO:0005035 death receptor activity GO:0030414 peptidase inhibitor activity GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD27 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD27 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD27 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD27 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD27 in various data sets.
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Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD27. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD27. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD27. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD27. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD27 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD27 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CD27 |
Name | CD27 molecule |
Aliases | S152; TNFRSF7; tumor necrosis factor receptor superfamily, member 7; S152. LPFS2; T14; CD27L receptor; T cel ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD27 collected from DrugBank database. |
There is no record. |