Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Domain |
PF00047 Immunoglobulin domain PF07686 Immunoglobulin V-set domain |
Function |
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). |
Biological Process | - |
Molecular Function |
GO:0030246 carbohydrate binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CD33 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CD33 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CD33 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CD33 in various data sets.
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Points in the above scatter plot represent the mutation difference of CD33 in various data sets.
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Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD33. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD33. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD33. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD33. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CD33 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CD33 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CD33 |
Name | CD33 molecule |
Aliases | SIGLEC3; SIGLEC-3; FLJ00391; sialic acid binding Ig-like lectin 3; CD33 antigen (gp67); gp67; sialic acid-bi ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CD33 collected from DrugBank database. |
Details on drugs targeting CD33.
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